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- W2039764080 abstract "Microtubules are polymers composed of α-β tubulin heterodimers that assemble into microtubules [1Nogales E. Wolf S.G. Downing K.H. Structure of the alpha beta tubulin dimer by electron crystallography.Nature. 1998; 391: 199-203Crossref PubMed Scopus (1715) Google Scholar]. Microtubules are dynamic structures that have periods of both growth and shrinkage by addition and removal of subunits from the polymer [2Desai A. Mitchison T.J. Microtubule polymerization dynamics.Annu. Rev. Cell Dev. Biol. 1997; 13: 83-117Crossref PubMed Scopus (1822) Google Scholar]. Microtubules stochastically switch between periods of growth and shrinkage, termed dynamic instability [3Mitchison T. Kirschner M. Dynamic instability of microtubule growth.Nature. 1984; 312: 237-242Crossref PubMed Scopus (2160) Google Scholar]. Dynamic instability is coupled to the GTPase activity of the β-tubulin subunit of the tubulin heterodimer [4Davis A. Sage C.R. Dougherty C.A. Farrell K.W. Microtubule dynamics modulated by guanosine triphosphate hydrolysis activity of beta-tubulin.Science. 1994; 264: 839-842Crossref PubMed Scopus (51) Google Scholar]. Microtubule dynamics are regulated by microtubule-associated proteins (MAPs) that interact with microtubules to regulate dynamic instability [5Drewes G. Ebneth A. Mandelkow E.M. MAPs, MARKs and microtubule dynamics.Trends Biochem. Sci. 1998; 23: 307-311Abstract Full Text Full Text PDF PubMed Scopus (270) Google Scholar]. MAPs in budding yeast have been identified that bind microtubule ends (Bim1), that stabilize microtubule structures (Stu2), that bundle microtubules by forming cross-bridges (Ase1), and that interact with microtubules at the kinetochore (Cin8, Kar3, Kip3) [6Tirnauer J.S. O'Toole E. Berrueta L. Bierer B.E. Pellman D. Yeast Bim1p promotes the G1-specific dynamics of microtubules.J. Cell Biol. 1999; 145: 993-1007Crossref PubMed Scopus (200) Google Scholar, 7Usui T. Maekawa H. Pereira G. Schiebel E. The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage.EMBO J. 2003; 22: 4779-4793Crossref PubMed Scopus (62) Google Scholar, 8Schuyler S.C. Liu J.Y. Pellman D. The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.J. Cell Biol. 2003; 160: 517-528Crossref PubMed Scopus (162) Google Scholar, 9de Gramont A. Barbour L. Ross K.E. Cohen-Fix O. The spindle midzone microtubule-associated proteins Ase1p and Cin8p affect the number and orientation of astral microtubules in Saccharomyces cerevisiae.Cell Cycle. 2007; 6: 1231-1241Crossref PubMed Scopus (11) Google Scholar, 10Endow S.A. Kang S.J. Satterwhite L.L. Rose M.D. Skeen V.P. Salmon E.D. Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.EMBO J. 1994; 13: 2708-2713Crossref PubMed Scopus (232) Google Scholar]. IRC15 was previously identified in four different genetic screens for mutants affecting chromosome transmission or repair [11Daniel J.A. Keyes B.E. Ng Y.P.Y. Freeman C.O. Burke D.J. Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae.Genetics. 2006; 172: 53-65Crossref PubMed Scopus (45) Google Scholar, 12Alvaro D. Lisby M. Rothstein R. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.PLoS Genet. 2007; 3: e228Crossref PubMed Scopus (135) Google Scholar, 13Measday V. Baetz K. Guzzo J. Yuen K. Kwok T. Sheikh B. Ding H. Ueta R. Hoac T. Cheng B. et al.Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.Proc. Natl. Acad. Sci. USA. 2005; 102: 13956-13961Crossref PubMed Scopus (108) Google Scholar, 14Jordan P.W. Klein F. Leach D.R. Novel roles for selected genes in meiotic DNA processing.PLoS Genet. 2007; 3: e222Crossref PubMed Scopus (26) Google Scholar]. Here we present evidence that Irc15 is a microtubule-associated protein, localizing to microtubules in vivo and binding to purified microtubules in vitro. Irc15 regulates microtubule dynamics in vivo and loss of IRC15 function leads to delayed mitotic progression, resulting from failure to establish tension between sister kinetochores." @default.
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- W2039764080 date "2009-03-01" @default.
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- W2039764080 title "Irc15 Is a Microtubule-Associated Protein that Regulates Microtubule Dynamics in Saccharomyces cerevisiae" @default.
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- W2039764080 doi "https://doi.org/10.1016/j.cub.2009.01.068" @default.
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