Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039769788> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2039769788 endingPage "117" @default.
- W2039769788 startingPage "111" @default.
- W2039769788 abstract "Native, denatured, performic acid-oxidized or S-sulfo insulin and S-sulfo or performic acid-oxidized A- and B-chains were digested with subtilisin type Carlsberg. The proteolysis was followed by measuring the uptake of alkali through autotitration. The kinetic study shows the existence of 2 first-order reaction classes which differ markedly in rate constant. The number of bonds split with fast and with slow reactions has been calculated. Only one of a total of 12 cleavable bonds in native insulin is opened by fast reaction. In the denatured protein the number of bonds split by the fast reaction increases to 4 and in the oxidized and S-sulfo protein 3 bonds are cleaved, while the slow cleavable bonds number 8 and 7, respectively. The kinetic study of the proteolysis of S-sulfo A-chain and of oxidized or S-sulfo B-chain shows that two bonds are split in A-chain with the fast and slow reactions, while in B-chain only one of the six cleavable bonds is susceptible to fast attack." @default.
- W2039769788 created "2016-06-24" @default.
- W2039769788 creator A5016848821 @default.
- W2039769788 creator A5018559525 @default.
- W2039769788 creator A5036175109 @default.
- W2039769788 creator A5043199946 @default.
- W2039769788 creator A5091408112 @default.
- W2039769788 date "2009-01-12" @default.
- W2039769788 modified "2023-09-24" @default.
- W2039769788 title "DIGESTION OF INSULIN DERIVATIVES WITH SUBTILISIN: A KINETIC STUDY" @default.
- W2039769788 cites W1968835537 @default.
- W2039769788 cites W2054716663 @default.
- W2039769788 cites W2067044612 @default.
- W2039769788 cites W207768927 @default.
- W2039769788 cites W2171513964 @default.
- W2039769788 cites W2328104816 @default.
- W2039769788 cites W2912851500 @default.
- W2039769788 doi "https://doi.org/10.1111/j.1399-3011.1975.tb02420.x" @default.
- W2039769788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/237842" @default.
- W2039769788 hasPublicationYear "2009" @default.
- W2039769788 type Work @default.
- W2039769788 sameAs 2039769788 @default.
- W2039769788 citedByCount "2" @default.
- W2039769788 crossrefType "journal-article" @default.
- W2039769788 hasAuthorship W2039769788A5016848821 @default.
- W2039769788 hasAuthorship W2039769788A5018559525 @default.
- W2039769788 hasAuthorship W2039769788A5036175109 @default.
- W2039769788 hasAuthorship W2039769788A5043199946 @default.
- W2039769788 hasAuthorship W2039769788A5091408112 @default.
- W2039769788 hasConcept C121332964 @default.
- W2039769788 hasConcept C135889238 @default.
- W2039769788 hasConcept C178790620 @default.
- W2039769788 hasConcept C181199279 @default.
- W2039769788 hasConcept C185592680 @default.
- W2039769788 hasConcept C2778432551 @default.
- W2039769788 hasConcept C2779811187 @default.
- W2039769788 hasConcept C2781307694 @default.
- W2039769788 hasConcept C2781357212 @default.
- W2039769788 hasConcept C31684184 @default.
- W2039769788 hasConcept C43617362 @default.
- W2039769788 hasConcept C62520636 @default.
- W2039769788 hasConceptScore W2039769788C121332964 @default.
- W2039769788 hasConceptScore W2039769788C135889238 @default.
- W2039769788 hasConceptScore W2039769788C178790620 @default.
- W2039769788 hasConceptScore W2039769788C181199279 @default.
- W2039769788 hasConceptScore W2039769788C185592680 @default.
- W2039769788 hasConceptScore W2039769788C2778432551 @default.
- W2039769788 hasConceptScore W2039769788C2779811187 @default.
- W2039769788 hasConceptScore W2039769788C2781307694 @default.
- W2039769788 hasConceptScore W2039769788C2781357212 @default.
- W2039769788 hasConceptScore W2039769788C31684184 @default.
- W2039769788 hasConceptScore W2039769788C43617362 @default.
- W2039769788 hasConceptScore W2039769788C62520636 @default.
- W2039769788 hasIssue "2" @default.
- W2039769788 hasLocation W20397697881 @default.
- W2039769788 hasLocation W20397697882 @default.
- W2039769788 hasOpenAccess W2039769788 @default.
- W2039769788 hasPrimaryLocation W20397697881 @default.
- W2039769788 hasRelatedWork W1836593413 @default.
- W2039769788 hasRelatedWork W2023255531 @default.
- W2039769788 hasRelatedWork W2036142693 @default.
- W2039769788 hasRelatedWork W2039769788 @default.
- W2039769788 hasRelatedWork W2043505722 @default.
- W2039769788 hasRelatedWork W2048632776 @default.
- W2039769788 hasRelatedWork W2062882752 @default.
- W2039769788 hasRelatedWork W2097086424 @default.
- W2039769788 hasRelatedWork W2403947567 @default.
- W2039769788 hasRelatedWork W3118216749 @default.
- W2039769788 hasVolume "7" @default.
- W2039769788 isParatext "false" @default.
- W2039769788 isRetracted "false" @default.
- W2039769788 magId "2039769788" @default.
- W2039769788 workType "article" @default.