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• W2039771431 startingPage "e1003367" @default.
• W2039771431 abstract "Although extensively studied, the structure, cellular origin and assembly mechanism of internal membranes during viral infection remain unclear. By combining diverse imaging techniques, including the novel Scanning-Transmission Electron Microscopy tomography, we elucidate the structural stages of membrane biogenesis during the assembly of the giant DNA virus Mimivirus. We show that this elaborate multistage process occurs at a well-defined zone localized at the periphery of large viral factories that are generated in the host cytoplasm. Membrane biogenesis is initiated by fusion of multiple vesicles, ∼70 nm in diameter, that apparently derive from the host ER network and enable continuous supply of lipid components to the membrane-assembly zone. The resulting multivesicular bodies subsequently rupture to form large open single-layered membrane sheets from which viral membranes are generated. Membrane generation is accompanied by the assembly of icosahedral viral capsids in a process involving the hypothetical major capsid protein L425 that acts as a scaffolding protein. The assembly model proposed here reveals how multiple Mimivirus progeny can be continuously and efficiently generated and underscores the similarity between the infection cycles of Mimivirus and Vaccinia virus. Moreover, the membrane biogenesis process indicated by our findings provides new insights into the pathways that might mediate assembly of internal viral membranes in general." @default.
• W2039771431 created "2016-06-24" @default.
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• W2039771431 date "2013-05-30" @default.
• W2039771431 modified "2023-10-02" @default.
• W2039771431 title "Membrane Assembly during the Infection Cycle of the Giant Mimivirus" @default.
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• W2039771431 doi "https://doi.org/10.1371/journal.ppat.1003367" @default.
• W2039771431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3667779" @default.
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• W2039771431 hasPublicationYear "2013" @default.
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