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- W2039772231 abstract "SEREX has been applied to esophageal SCC, and the TRIM21 gene was identified as a novel SEREX antigen of esophageal SCC. The presence of s‐TRIM21‐Abs was confirmed by Western blotting using bacterially expressed TRIM21 gene product and was evaluated for clinicopathological significance in patients with esophageal SCC. s‐TRIM21‐Abs were detected in 18 (20%) of 91 patients with esophageal SCC but not in 42 healthy donors. The presence of s‐TRIM21‐Abs was partly associated with tumor size ( P = 0.063) and poor survival ( P = 0.067). To measure serum antibody levels, ELISA using purified recombinant TRIM21 protein was developed. The levels of s‐TRIM21‐Abs were significantly higher in patients with esophageal SCC than in healthy donors ( P = 0.013). s‐TRIM21‐Abs may be a useful tumor marker to diagnose and predict disease progression in patients with esophageal SCC. ( Cancer Sci 2006; 97: 380–386)" @default.
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- W2039772231 date "2006-04-10" @default.
- W2039772231 modified "2023-10-17" @default.
- W2039772231 title "Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma" @default.
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- W2039772231 doi "https://doi.org/10.1111/j.1349-7006.2006.00192.x" @default.
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