Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039773532> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2039773532 endingPage "170" @default.
- W2039773532 startingPage "168" @default.
- W2039773532 abstract "An animal model for Menkes' kinky hair syndrome is provided by mice mutant at the X-linked mottled locus. Two mechanisms have been invoked to explain disease manifestations in mottled and in kinky hair syndrome: relative tissue copper deficiencies and corresponding reductions in cuproenzyme activities; or defective intracellular copper utilization, with impaired intracellular translocation to cuproenzymes or to copper-dependent processes. We addressed the second possibility through measurements of soluble superoxide dismutase (SOD-1) in cytosol extracts of confluent mottled (blotchy) cultured skin fibroblasts. At comparable intracellular copper concentrations over a broad range, SOD-1 specific activities in the mutant cells were not distinguishable from those in controls, or, in some instances, were actually higher. These data suggest that the excess copper anomalously sequestered in a cell expressing the mutation remains available for binding to a cytosolic cuproenzyme. When taken together with data in other systems, the results are consistent with the thesis that the basic lesion in blotchy may primarily affect copper transport or delivery to specific copper transport systems." @default.
- W2039773532 created "2016-06-24" @default.
- W2039773532 creator A5022254784 @default.
- W2039773532 creator A5034327505 @default.
- W2039773532 creator A5065085371 @default.
- W2039773532 date "1984-02-10" @default.
- W2039773532 modified "2023-10-13" @default.
- W2039773532 title "Copper utilization in cultured skin fibroblasts of the mottled mouse, an animal model for Menkes' kinky hair syndrome" @default.
- W2039773532 cites W1529036811 @default.
- W2039773532 cites W1578307824 @default.
- W2039773532 cites W1933729639 @default.
- W2039773532 cites W1968051017 @default.
- W2039773532 cites W2006428216 @default.
- W2039773532 cites W2019584574 @default.
- W2039773532 cites W2029756351 @default.
- W2039773532 cites W2031423487 @default.
- W2039773532 cites W2059671218 @default.
- W2039773532 cites W2076705470 @default.
- W2039773532 cites W4211062926 @default.
- W2039773532 cites W4737060 @default.
- W2039773532 doi "https://doi.org/10.1007/bf01805602" @default.
- W2039773532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6441865" @default.
- W2039773532 hasPublicationYear "1984" @default.
- W2039773532 type Work @default.
- W2039773532 sameAs 2039773532 @default.
- W2039773532 citedByCount "15" @default.
- W2039773532 crossrefType "journal-article" @default.
- W2039773532 hasAuthorship W2039773532A5022254784 @default.
- W2039773532 hasAuthorship W2039773532A5034327505 @default.
- W2039773532 hasAuthorship W2039773532A5065085371 @default.
- W2039773532 hasConcept C104317684 @default.
- W2039773532 hasConcept C142724271 @default.
- W2039773532 hasConcept C143065580 @default.
- W2039773532 hasConcept C178790620 @default.
- W2039773532 hasConcept C181199279 @default.
- W2039773532 hasConcept C185592680 @default.
- W2039773532 hasConcept C2775838275 @default.
- W2039773532 hasConcept C2777106986 @default.
- W2039773532 hasConcept C2777581567 @default.
- W2039773532 hasConcept C2781156865 @default.
- W2039773532 hasConcept C2991729501 @default.
- W2039773532 hasConcept C544778455 @default.
- W2039773532 hasConcept C55493867 @default.
- W2039773532 hasConcept C71924100 @default.
- W2039773532 hasConcept C79879829 @default.
- W2039773532 hasConcept C84597430 @default.
- W2039773532 hasConcept C86803240 @default.
- W2039773532 hasConcept C95444343 @default.
- W2039773532 hasConcept C98539663 @default.
- W2039773532 hasConceptScore W2039773532C104317684 @default.
- W2039773532 hasConceptScore W2039773532C142724271 @default.
- W2039773532 hasConceptScore W2039773532C143065580 @default.
- W2039773532 hasConceptScore W2039773532C178790620 @default.
- W2039773532 hasConceptScore W2039773532C181199279 @default.
- W2039773532 hasConceptScore W2039773532C185592680 @default.
- W2039773532 hasConceptScore W2039773532C2775838275 @default.
- W2039773532 hasConceptScore W2039773532C2777106986 @default.
- W2039773532 hasConceptScore W2039773532C2777581567 @default.
- W2039773532 hasConceptScore W2039773532C2781156865 @default.
- W2039773532 hasConceptScore W2039773532C2991729501 @default.
- W2039773532 hasConceptScore W2039773532C544778455 @default.
- W2039773532 hasConceptScore W2039773532C55493867 @default.
- W2039773532 hasConceptScore W2039773532C71924100 @default.
- W2039773532 hasConceptScore W2039773532C79879829 @default.
- W2039773532 hasConceptScore W2039773532C84597430 @default.
- W2039773532 hasConceptScore W2039773532C86803240 @default.
- W2039773532 hasConceptScore W2039773532C95444343 @default.
- W2039773532 hasConceptScore W2039773532C98539663 @default.
- W2039773532 hasIssue "4" @default.
- W2039773532 hasLocation W20397735321 @default.
- W2039773532 hasLocation W20397735322 @default.
- W2039773532 hasOpenAccess W2039773532 @default.
- W2039773532 hasPrimaryLocation W20397735321 @default.
- W2039773532 hasRelatedWork W1509211173 @default.
- W2039773532 hasRelatedWork W1965482537 @default.
- W2039773532 hasRelatedWork W1999084257 @default.
- W2039773532 hasRelatedWork W2015292111 @default.
- W2039773532 hasRelatedWork W2081991809 @default.
- W2039773532 hasRelatedWork W2109928864 @default.
- W2039773532 hasRelatedWork W2181723874 @default.
- W2039773532 hasRelatedWork W2254672208 @default.
- W2039773532 hasRelatedWork W2513411289 @default.
- W2039773532 hasRelatedWork W4256341963 @default.
- W2039773532 hasVolume "7" @default.
- W2039773532 isParatext "false" @default.
- W2039773532 isRetracted "false" @default.
- W2039773532 magId "2039773532" @default.
- W2039773532 workType "article" @default.