FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039780251> ?p ?o ?g. }

• W2039780251 endingPage "36" @default.
• W2039780251 startingPage "23" @default.
• W2039780251 abstract "The discovery that the dominant X-linked form of Charcot-Marie-Tooth disease (CMTX), a genetic disease of the peripheral nervous system (PNS), is associated with mutations in connexin32 (Cx32) has brought attention to the importance of connexins in glial cell biology. To gain further insight into the consequences of Cx32 deficiency, we have undertaken a detailed characterization of the gene expression profile of Schwann cells isolated from the sciatic nerve of wild-type and Cx32-null mice. Schwann cells exhibit two distinct phenotypes, myelinating and nonmyelinating, which are defined by their different morphology with respect to axons and by their unique profile of gene expression. Our findings show that, regardless of the mouse genotype, cultured Schwann cells express similar levels of messages for a number of connexins and for genes characteristic of both the myelinating and the nonmyelinating phenotypes. Furthermore, we have identified Cx36, a member of the gamma subclass of connexins, which are preferentially expressed in neuronal cells of mouse brain and retina, as an additional connexin present in Schwann cells. Mice lacking Cx32, however, exhibited a marked up-regulation of glial fibrillary acidic protein (GFAP), a cytoskeletal protein usually synthesized only by nonmyelinating Schwann cells. This observation was extended to the PNS in vivo and did not reflect a general perturbation of the expression of other nonmyelinating Schwann cell genes. These findings demonstrate that the absence of Cx32 results in a distinct pattern of gene dysregulation in Schwann cells and that Schwann cell homeostasis is critically dependent on the correct expression of Cx32 and not just any connexin. Identifying the relationship between increased GFAP expression and the absence of Cx32 could lead to the definition of specific roles for Cx32 in the control of myelin homeostasis and in the development of CMTX." @default.
• W2039780251 created "2016-06-24" @default.
• W2039780251 creator A5019563931 @default.
• W2039780251 creator A5027193785 @default.
• W2039780251 creator A5056739204 @default.
• W2039780251 creator A5082612357 @default.
• W2039780251 date "2001-09-26" @default.
• W2039780251 modified "2023-10-18" @default.
• W2039780251 title "Altered gene expression in Schwann cells of connexin32 knockout animals" @default.
• W2039780251 cites W125633551 @default.
• W2039780251 cites W1493453867 @default.
• W2039780251 cites W1544475860 @default.
• W2039780251 cites W1557488126 @default.
• W2039780251 cites W1578786288 @default.
• W2039780251 cites W178338362 @default.
• W2039780251 cites W1922888525 @default.
• W2039780251 cites W1965331909 @default.
• W2039780251 cites W1967949725 @default.
• W2039780251 cites W1970564163 @default.
• W2039780251 cites W1971627794 @default.
• W2039780251 cites W1976138487 @default.
• W2039780251 cites W1977845454 @default.
• W2039780251 cites W1985284746 @default.
• W2039780251 cites W1987885030 @default.
• W2039780251 cites W1991815902 @default.
• W2039780251 cites W1992162703 @default.
• W2039780251 cites W1993807136 @default.
• W2039780251 cites W2001939571 @default.
• W2039780251 cites W2003439439 @default.
• W2039780251 cites W2013736577 @default.
• W2039780251 cites W2014105239 @default.
• W2039780251 cites W2017688904 @default.
• W2039780251 cites W2026354521 @default.
• W2039780251 cites W2026523931 @default.
• W2039780251 cites W2027196477 @default.
• W2039780251 cites W2032171471 @default.
• W2039780251 cites W2036430171 @default.
• W2039780251 cites W2039422779 @default.
• W2039780251 cites W2043654463 @default.
• W2039780251 cites W2046434701 @default.
• W2039780251 cites W2047669413 @default.
• W2039780251 cites W2049648491 @default.
• W2039780251 cites W2051738169 @default.
• W2039780251 cites W2053349223 @default.
• W2039780251 cites W2053369913 @default.
• W2039780251 cites W2056521724 @default.
• W2039780251 cites W2058730842 @default.
• W2039780251 cites W2065505689 @default.
• W2039780251 cites W2065965177 @default.
• W2039780251 cites W2073529536 @default.
• W2039780251 cites W2080202616 @default.
• W2039780251 cites W2080747538 @default.
• W2039780251 cites W2081432333 @default.
• W2039780251 cites W2087138604 @default.
• W2039780251 cites W2087263333 @default.
• W2039780251 cites W2089550182 @default.
• W2039780251 cites W2089924025 @default.
• W2039780251 cites W2090621635 @default.
• W2039780251 cites W2091238338 @default.
• W2039780251 cites W2100160742 @default.
• W2039780251 cites W2110234511 @default.
• W2039780251 cites W2121271552 @default.
• W2039780251 cites W2122678512 @default.
• W2039780251 cites W2124809764 @default.
• W2039780251 cites W2132468193 @default.
• W2039780251 cites W2134309097 @default.
• W2039780251 cites W2138766780 @default.
• W2039780251 cites W2140926801 @default.
• W2039780251 cites W2145599313 @default.
• W2039780251 cites W2146984840 @default.
• W2039780251 cites W2149545106 @default.
• W2039780251 cites W2162919223 @default.
• W2039780251 cites W2169917556 @default.
• W2039780251 cites W2171246208 @default.
• W2039780251 cites W2266209009 @default.
• W2039780251 cites W4248317500 @default.
• W2039780251 doi "https://doi.org/10.1002/jnr.1194" @default.
• W2039780251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11598999" @default.
• W2039780251 hasPublicationYear "2001" @default.
• W2039780251 type Work @default.
• W2039780251 sameAs 2039780251 @default.
• W2039780251 citedByCount "24" @default.
• W2039780251 countsByYear W20397802512013 @default.
• W2039780251 countsByYear W20397802512018 @default.
• W2039780251 countsByYear W20397802512023 @default.
• W2039780251 crossrefType "journal-article" @default.
• W2039780251 hasAuthorship W2039780251A5019563931 @default.
• W2039780251 hasAuthorship W2039780251A5027193785 @default.
• W2039780251 hasAuthorship W2039780251A5056739204 @default.
• W2039780251 hasAuthorship W2039780251A5082612357 @default.
• W2039780251 hasConcept C104317684 @default.
• W2039780251 hasConcept C127716648 @default.
• W2039780251 hasConcept C158157758 @default.
• W2039780251 hasConcept C169760540 @default.
• W2039780251 hasConcept C203014093 @default.
• W2039780251 hasConcept C204232928 @default.
• W2039780251 hasConcept C2777004073 @default.
• W2039780251 hasConcept C2778609137 @default.

• next