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• W2039781333 endingPage "e27438" @default.
• W2039781333 startingPage "e27438" @default.
• W2039781333 abstract "Dysfunction of hepatocyte nuclear factor 4α (HNF4α) has been linked to maturity onset diabetes of the young (MODY1), diabetes type II and possibly to renal cell carcinoma (RCC). Whereas diabetes causing mutations are well known, there are no HNF4A mutations found in RCC. Since so far analyses have been constricted to the promoter and open reading frame of HNF4A, we performed a systematic analysis of the human HNF4A 3′UTR. We identified a short (1724 nt) and long (3180 nt) 3′UTR that are much longer than the open reading frame and conferred a repressive effect in luciferase reporter assays in HEK293 and INS-1 cells. By dissecting the 3′UTR into several pieces, we located two distinct elements of about 400 nt conferring a highly repressive effect. These negative elements A and B are counteracted by a balancer element of 39 nt located within the 5′ end of the HNF4A 3′UTR. Dicer knock-down experiments implied that the HNF4A 3′UTR is regulated by miRNAs. More detailed analysis showed that miR-34a and miR-21 both overexpressed in RCC cooperate in downregulation of the HNF4A mRNA. One of the identified miR-34a binding sites is destroyed by SNP rs11574744. The identification of several regulatory elements within the HNF4A 3′UTR justifies the analysis of the 3′UTR sequence to explore the dysfunction of HNF4α in diabetes and RCC." @default.
• W2039781333 created "2016-06-24" @default.
• W2039781333 creator A5009672391 @default.
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• W2039781333 creator A5053709388 @default.
• W2039781333 date "2011-11-30" @default.
• W2039781333 modified "2023-10-18" @default.
• W2039781333 title "A Systematic Analysis of the 3′UTR of HNF4A mRNA Reveals an Interplay of Regulatory Elements Including miRNA Target Sites" @default.
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• W2039781333 cites W1965314708 @default.
• W2039781333 cites W1972408423 @default.
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• W2039781333 cites W1979297613 @default.
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• W2039781333 cites W1981913640 @default.
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• W2039781333 cites W2006426795 @default.
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• W2039781333 cites W2026354664 @default.
• W2039781333 cites W2027989791 @default.
• W2039781333 cites W2028164074 @default.
• W2039781333 cites W2030166934 @default.
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• W2039781333 cites W2068577315 @default.
• W2039781333 cites W2070765029 @default.
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• W2039781333 doi "https://doi.org/10.1371/journal.pone.0027438" @default.
• W2039781333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3227676" @default.
• W2039781333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22140441" @default.
• W2039781333 hasPublicationYear "2011" @default.
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