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- W2039782308 endingPage "180" @default.
- W2039782308 startingPage "171" @default.
- W2039782308 abstract "Despite vaccines and antiviral substances influenza still causes significant morbidity and mortality world wide. Better understanding of the molecular mechanisms of influenza virus replication, pathogenesis and host immune responses is required for the development of more efficient means of prevention and treatment of influenza. Influenza A virus, which replicates in epithelial cells and leukocytes, regulates host cell transcriptional and translational systems and activates, as well as downregulates apoptotic pathways. Influenza A virus infection results in the production of chemotactic (RANTES, MIP-1α, MCP-1, MCP-3, and IP-10), pro-inflammatory (IL-1β, IL-6, IL-18, and TNF-α), and antiviral (IFN-α/β) cytokines. Cytokine gene expression is associated with the activation of NF-κB, AP-1, STAT and IRF signal transducing molecules in influenza A virus-infected cells. In addition of upregulating cytokine gene expression, influenza A virus infection activates caspase-1 enzyme, which is involved in the proteolytic processing of proIL-1β and proIL-18 into their biologically active forms. Influenza A virus-induced IFN-α/β is essential in host's antiviral defence by activating the expression of antiviral Mx, PKR and oligoadenylate synthetase genes. IFN-α/β also prolongs T cell survival, upregulates IL-12 and IL-18 receptor gene expression and together with IL-18 stimulates NK and T cell IFN-γ production and the development of Th1-type immune response." @default.
- W2039782308 created "2016-06-24" @default.
- W2039782308 creator A5007995979 @default.
- W2039782308 date "2001-06-01" @default.
- W2039782308 modified "2023-10-17" @default.
- W2039782308 title "Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression" @default.
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- W2039782308 doi "https://doi.org/10.1016/s1359-6101(00)00026-5" @default.
- W2039782308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11325600" @default.
- W2039782308 hasPublicationYear "2001" @default.
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