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- W2039783492 abstract "Membranous nephropathy is characterised by the deposition of immunoglobulin, predominantly of the IgG4 subclass, along the epithelial surface of the glomerular-basement membrane. Current models of pathogenesis usually assume in-situ immune-complex formation involving an as yet uncharacterised fixed glomerular antigen. I argue that the properties of IgG4 (inability to fix complement and therefore impaired clearance of IgG4-containing complexes; low affinity and therefore ability for IgG4-containing complexes to dissociate and traverse the glomerular-basement membrane) are compatible with a pathogenic mechanism that involves the deposition of circulating IgG4 immune complexes containing diverse antigens." @default.
- W2039783492 created "2016-06-24" @default.
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- W2039783492 date "1998-02-01" @default.
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- W2039783492 title "Membranous nephropathy: an IgG4-mediated disease" @default.
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- W2039783492 doi "https://doi.org/10.1016/s0140-6736(97)04122-6" @default.
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