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• W2039784709 abstract "Innate immune responses induced by the pattern-recognition receptors Nod1 and Nod2 play pivotal roles to combat infection and to instruct adaptive immunity. Here we identify Ankrd17 as a novel binding partner of Nod2 and show that its N-terminal domain mediates Nod2 binding. Knock-down and overexpression analysis revealed that Ankrd17 is functionally involved in Nod2- and Nod1-mediated responses in human myeloid and epithelial cells. In HeLa cells Ankrd17 contributed to pro-inflammatory responses induced by Shigella flexneri, however not to type I interferon responses induced by Sendai virus. In conclusion, this reveals a novel function for Ankrd17 in anti-bacterial innate immune pathways." @default.
• W2039784709 created "2016-06-24" @default.
• W2039784709 creator A5016791531 @default.
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• W2039784709 date "2013-05-24" @default.
• W2039784709 modified "2023-10-13" @default.
• W2039784709 title "A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses" @default.
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• W2039784709 doi "https://doi.org/10.1016/j.febslet.2013.05.037" @default.
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