Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039788123> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2039788123 endingPage "969" @default.
- W2039788123 startingPage "962" @default.
- W2039788123 abstract "Background: The administration of insulin has been shown to exert cardioprotective and immunomodulatory properties. Ischemia and inflammation are typical features of acute coronary syndrome, thus it was hypothesized that high-dose glucose–insulin–potassium (GIK) treatment could suppress the systemic inflammatory reaction and attenuate myocardial ischemia–reperfusion injury in patients with unstable angina pectoris after urgent coronary artery bypass surgery. Methods: Forty patients with unstable angina pectoris scheduled for urgent coronary artery bypass surgery and cardiopulmonary bypass were randomly assigned to receive either high-dose insulin treatment (short-acting insulin 1 IU/kg/h with 30% glucose 1.5 ml/kg/h administered separately) or control treatment (saline). Blood glucose levels were targeted to 6.0–8.0 mmol/l in both groups by adjusting the rate of glucose infusion in the GIK group and by additional insulin in the control group as needed. Results: High-dose insulin treatment was associated with significantly lower average C-reactive protein (23.8 vs. 40.1 mg/l, P= 0.008) and free fatty acid levels (0.22 vs. 0.41 mmol/l, P= < 0.001) post-operatively. Average blood glucose levels were comparable during the intensive care unit (ICU) stay (7.1 vs. 6.9 mmol/l, P= 0.5) and 95% of the control patients received supplemental insulin. The pro-inflammatory cytokine response [interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α)] did not differ between the groups and beneficial effects on myocardial injury were not detected. Conclusions: High-dose insulin treatment has potential anti-inflammatory properties independent of its ability to lower blood glucose levels. Even profound suppression of free fatty acid levels, the attenuation of myocardial ischemia–reperfusion injury was not detected." @default.
- W2039788123 created "2016-06-24" @default.
- W2039788123 creator A5011305654 @default.
- W2039788123 creator A5049824264 @default.
- W2039788123 creator A5054827447 @default.
- W2039788123 creator A5060570812 @default.
- W2039788123 creator A5073317929 @default.
- W2039788123 creator A5079227589 @default.
- W2039788123 creator A5086679479 @default.
- W2039788123 creator A5091159480 @default.
- W2039788123 date "2006-09-01" @default.
- W2039788123 modified "2023-09-27" @default.
- W2039788123 title "Anti-inflammatory effect of high-dose insulin treatment after urgent coronary revascularization surgery" @default.
- W2039788123 cites W1972508196 @default.
- W2039788123 cites W1980717583 @default.
- W2039788123 cites W2005636700 @default.
- W2039788123 cites W2016029167 @default.
- W2039788123 cites W2026869194 @default.
- W2039788123 cites W2036922676 @default.
- W2039788123 cites W2049881307 @default.
- W2039788123 cites W2057964637 @default.
- W2039788123 cites W2061050519 @default.
- W2039788123 cites W2069427959 @default.
- W2039788123 cites W2070076129 @default.
- W2039788123 cites W2083990676 @default.
- W2039788123 cites W2085906265 @default.
- W2039788123 cites W2107428530 @default.
- W2039788123 cites W2119693754 @default.
- W2039788123 cites W2123560318 @default.
- W2039788123 cites W2144594334 @default.
- W2039788123 cites W2151169124 @default.
- W2039788123 cites W2154915517 @default.
- W2039788123 cites W2158220397 @default.
- W2039788123 cites W2315575691 @default.
- W2039788123 doi "https://doi.org/10.1111/j.1399-6576.2006.01100.x" @default.
- W2039788123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16923091" @default.
- W2039788123 hasPublicationYear "2006" @default.
- W2039788123 type Work @default.
- W2039788123 sameAs 2039788123 @default.
- W2039788123 citedByCount "43" @default.
- W2039788123 countsByYear W20397881232012 @default.
- W2039788123 countsByYear W20397881232013 @default.
- W2039788123 countsByYear W20397881232014 @default.
- W2039788123 countsByYear W20397881232015 @default.
- W2039788123 countsByYear W20397881232019 @default.
- W2039788123 countsByYear W20397881232022 @default.
- W2039788123 countsByYear W20397881232023 @default.
- W2039788123 crossrefType "journal-article" @default.
- W2039788123 hasAuthorship W2039788123A5011305654 @default.
- W2039788123 hasAuthorship W2039788123A5049824264 @default.
- W2039788123 hasAuthorship W2039788123A5054827447 @default.
- W2039788123 hasAuthorship W2039788123A5060570812 @default.
- W2039788123 hasAuthorship W2039788123A5073317929 @default.
- W2039788123 hasAuthorship W2039788123A5079227589 @default.
- W2039788123 hasAuthorship W2039788123A5086679479 @default.
- W2039788123 hasAuthorship W2039788123A5091159480 @default.
- W2039788123 hasConcept C126322002 @default.
- W2039788123 hasConcept C164705383 @default.
- W2039788123 hasConcept C2776376669 @default.
- W2039788123 hasConcept C2776820930 @default.
- W2039788123 hasConcept C2777785093 @default.
- W2039788123 hasConcept C2778425758 @default.
- W2039788123 hasConcept C2778881276 @default.
- W2039788123 hasConcept C2779306644 @default.
- W2039788123 hasConcept C42219234 @default.
- W2039788123 hasConcept C500558357 @default.
- W2039788123 hasConcept C71924100 @default.
- W2039788123 hasConceptScore W2039788123C126322002 @default.
- W2039788123 hasConceptScore W2039788123C164705383 @default.
- W2039788123 hasConceptScore W2039788123C2776376669 @default.
- W2039788123 hasConceptScore W2039788123C2776820930 @default.
- W2039788123 hasConceptScore W2039788123C2777785093 @default.
- W2039788123 hasConceptScore W2039788123C2778425758 @default.
- W2039788123 hasConceptScore W2039788123C2778881276 @default.
- W2039788123 hasConceptScore W2039788123C2779306644 @default.
- W2039788123 hasConceptScore W2039788123C42219234 @default.
- W2039788123 hasConceptScore W2039788123C500558357 @default.
- W2039788123 hasConceptScore W2039788123C71924100 @default.
- W2039788123 hasIssue "8" @default.
- W2039788123 hasLocation W20397881231 @default.
- W2039788123 hasLocation W20397881232 @default.
- W2039788123 hasOpenAccess W2039788123 @default.
- W2039788123 hasPrimaryLocation W20397881231 @default.
- W2039788123 hasRelatedWork W154185416 @default.
- W2039788123 hasRelatedWork W1574348006 @default.
- W2039788123 hasRelatedWork W1972005328 @default.
- W2039788123 hasRelatedWork W1978545486 @default.
- W2039788123 hasRelatedWork W2006575881 @default.
- W2039788123 hasRelatedWork W2037621173 @default.
- W2039788123 hasRelatedWork W2049397185 @default.
- W2039788123 hasRelatedWork W2054509747 @default.
- W2039788123 hasRelatedWork W2135975603 @default.
- W2039788123 hasRelatedWork W2911729115 @default.
- W2039788123 hasVolume "50" @default.
- W2039788123 isParatext "false" @default.
- W2039788123 isRetracted "false" @default.
- W2039788123 magId "2039788123" @default.
- W2039788123 workType "article" @default.