FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039796585> ?p ?o ?g. }

• W2039796585 endingPage "41" @default.
• W2039796585 startingPage "37" @default.
• W2039796585 abstract "Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) was recently identified as the first tissue-specific angiogenic molecule. EG-VEGF (the gene product of PROK-1) appears to be expressed exclusively in steroid-producing organs such as the ovary, testis, adrenals and placenta. Since the human pancreatic cells retain steroidogenic activity, in the present study we ascertained whether this angiogenic factor is expressed in normal pancreas and pancreatic adenocarcinoma. Tissue samples from normal males (n = 5), normal females (n = 5) and from surgically resected adenocarcinomas (n = 2) were processed for RT-PCR and immunohistochemical studies. Results from semi-quantitative analysis by RT-PCR suggest a distinct expression level for EG-VEGF in the different tissue samples. The relative amount of EG-VEGF mRNA in pancreas was more abundant in female adenocarcinoma (0.89) followed by male adenocarcinoma (0.71), than normal female (0.64) and normal male (0.38). The expression of mRNA for EG-VEGF in normal tissue was significantly higher in females than in males. All samples examined showed specific immunostaining for EG-VEGF. In male preparations, the positive labeling was localized predominantly within the pancreatic islets while in female preparations the main staining was detected towards the exocrine portion. Specific immunolabeling was also observed in endothelial cells of pancreatic blood vessels. Our data provide evidence that the human pancreas expresses the EG-VEGF, a highly specific mitogen which regulates proliferation and differentiation of the vascular endothelium. The significance of this finding could be interpreted as either, EG-VEGF is not exclusive of endocrine organs, or the pancreas should be considered as a functional steroidogenic tissue. The extent of the expression of EG-VEGF appears to have a dimorphic pattern in normal and tumoral pancreatic tissue." @default.
• W2039796585 created "2016-06-24" @default.
• W2039796585 creator A5020757101 @default.
• W2039796585 creator A5038152993 @default.
• W2039796585 creator A5041157859 @default.
• W2039796585 creator A5044352402 @default.
• W2039796585 creator A5056949839 @default.
• W2039796585 creator A5069215952 @default.
• W2039796585 date "2007-10-01" @default.
• W2039796585 modified "2023-10-18" @default.
• W2039796585 title "Expression and localization of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) in human pancreas and pancreatic adenocarcinoma" @default.
• W2039796585 cites W1549576586 @default.
• W2039796585 cites W1570883558 @default.
• W2039796585 cites W1679229092 @default.
• W2039796585 cites W1825488655 @default.
• W2039796585 cites W1878472746 @default.
• W2039796585 cites W1969240107 @default.
• W2039796585 cites W1981088207 @default.
• W2039796585 cites W2001123378 @default.
• W2039796585 cites W2001497420 @default.
• W2039796585 cites W2003820560 @default.
• W2039796585 cites W2010187478 @default.
• W2039796585 cites W2012366177 @default.
• W2039796585 cites W2027855683 @default.
• W2039796585 cites W2029802228 @default.
• W2039796585 cites W2060601927 @default.
• W2039796585 cites W2060782872 @default.
• W2039796585 cites W2074179147 @default.
• W2039796585 cites W2075985945 @default.
• W2039796585 cites W2095503539 @default.
• W2039796585 cites W2123126118 @default.
• W2039796585 cites W2125153669 @default.
• W2039796585 cites W2137353897 @default.
• W2039796585 cites W2154883606 @default.
• W2039796585 cites W2325304794 @default.
• W2039796585 cites W4236501921 @default.
• W2039796585 doi "https://doi.org/10.1016/j.jsbmb.2007.02.006" @default.
• W2039796585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17683928" @default.
• W2039796585 hasPublicationYear "2007" @default.
• W2039796585 type Work @default.
• W2039796585 sameAs 2039796585 @default.
• W2039796585 citedByCount "22" @default.
• W2039796585 countsByYear W20397965852012 @default.
• W2039796585 countsByYear W20397965852013 @default.
• W2039796585 countsByYear W20397965852014 @default.
• W2039796585 countsByYear W20397965852015 @default.
• W2039796585 countsByYear W20397965852017 @default.
• W2039796585 countsByYear W20397965852019 @default.
• W2039796585 countsByYear W20397965852021 @default.
• W2039796585 crossrefType "journal-article" @default.
• W2039796585 hasAuthorship W2039796585A5020757101 @default.
• W2039796585 hasAuthorship W2039796585A5038152993 @default.
• W2039796585 hasAuthorship W2039796585A5041157859 @default.
• W2039796585 hasAuthorship W2039796585A5044352402 @default.
• W2039796585 hasAuthorship W2039796585A5056949839 @default.
• W2039796585 hasAuthorship W2039796585A5069215952 @default.
• W2039796585 hasConcept C121608353 @default.
• W2039796585 hasConcept C126322002 @default.
• W2039796585 hasConcept C134018914 @default.
• W2039796585 hasConcept C167734588 @default.
• W2039796585 hasConcept C204232928 @default.
• W2039796585 hasConcept C2777025900 @default.
• W2039796585 hasConcept C2778764654 @default.
• W2039796585 hasConcept C2780210213 @default.
• W2039796585 hasConcept C2780394083 @default.
• W2039796585 hasConcept C2781182431 @default.
• W2039796585 hasConcept C4224716 @default.
• W2039796585 hasConcept C46699223 @default.
• W2039796585 hasConcept C502942594 @default.
• W2039796585 hasConcept C71315377 @default.
• W2039796585 hasConcept C71924100 @default.
• W2039796585 hasConcept C86803240 @default.
• W2039796585 hasConceptScore W2039796585C121608353 @default.
• W2039796585 hasConceptScore W2039796585C126322002 @default.
• W2039796585 hasConceptScore W2039796585C134018914 @default.
• W2039796585 hasConceptScore W2039796585C167734588 @default.
• W2039796585 hasConceptScore W2039796585C204232928 @default.
• W2039796585 hasConceptScore W2039796585C2777025900 @default.
• W2039796585 hasConceptScore W2039796585C2778764654 @default.
• W2039796585 hasConceptScore W2039796585C2780210213 @default.
• W2039796585 hasConceptScore W2039796585C2780394083 @default.
• W2039796585 hasConceptScore W2039796585C2781182431 @default.
• W2039796585 hasConceptScore W2039796585C4224716 @default.
• W2039796585 hasConceptScore W2039796585C46699223 @default.
• W2039796585 hasConceptScore W2039796585C502942594 @default.
• W2039796585 hasConceptScore W2039796585C71315377 @default.
• W2039796585 hasConceptScore W2039796585C71924100 @default.
• W2039796585 hasConceptScore W2039796585C86803240 @default.
• W2039796585 hasIssue "1-2" @default.
• W2039796585 hasLocation W20397965851 @default.
• W2039796585 hasLocation W20397965852 @default.
• W2039796585 hasOpenAccess W2039796585 @default.
• W2039796585 hasPrimaryLocation W20397965851 @default.
• W2039796585 hasRelatedWork W1508288034 @default.
• W2039796585 hasRelatedWork W1998091002 @default.
• W2039796585 hasRelatedWork W2011196179 @default.
• W2039796585 hasRelatedWork W2056872482 @default.
• W2039796585 hasRelatedWork W2062334532 @default.

• next