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- W2039804980 abstract "In order to compare the actions of interferons on the various pathways leading to human B-cell activation, we examined the effects of α-interferon (INF-α), β-interferon (INF-β), and γ-interferon (INF-γ) on B-cell responses to mitogenic stimuli which differ in their mode of B-cell stimulation. Utilizing highly purified small, dense peripheral blood B-cells or splenic lymphocytes, we demonstrate that (i) INF-α, -β, and -γ enhance human B-cell proliferation induced by cross-linking of surface Ig with either SAC or anti-μ in a dose-dependent fashion, analogous to and with a magnitude equal to or greater than that seen with human B-cell growth factor; (ii) INF-α and -β but not IFN-γ inhibit phorbol myristate acetate-mediated B-cell mitogenesis, again in a dose-dependent manner; and (iii) IFN-γ does not effect B-cell cytoplasmic calcium ([Ca2+]i) influx, either in the resting state or following stimulation with anti-μ, making it unlikely that IFN-γ exerts its stimulatory effects on B-cell function through changes in [Ca2+]i. Taken together, these findings suggest that all three types of interferons may have important immuno-regulatory roles in B-cell activity, and that their ability to enhance or suppress B-cell activation depends on the nature of the mitogenic stimulus." @default.
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- W2039804980 date "1988-09-01" @default.
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- W2039804980 title "Examination of the inhibitory and stimulatory effects of IFN-α, -β, and -γ on human B-cell proliferation induced by various B-cell mitogens" @default.
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- W2039804980 doi "https://doi.org/10.1016/0090-1229(88)90023-2" @default.
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