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- W2039824458 abstract "In normal individuals, γδ T cells account for less than 6% of total peripheral T lymphocytes and mainly express T-cell receptor (TCR) Vδ2-Vγ9 chains. We have previously observed a dramatic expansion of γδ T cells in the peripheral blood of renal allograft recipients only when they developed cytomegalovirus (CMV) infection. This increase was long lasting (more than 1 year), was associated with an activation of γδ T cells, and concerned only Vδ1 or Vδ3 T-cell subpopulations. Analysis of γδ TCR junctional diversity revealed that CMV infection in these patients was accompanied by (a) a marked restriction of CDR3 size distribution in Vδ3 and, to a lesser extent, in Vδ1 chains; and (b) a selective expansion of Vδ1 cells bearing recurrent junctional amino acid motifs. These features are highly suggestive of an in vivo antigen-driven selection of γδ T-cell subsets during the course of CMV infection. Furthermore, Vδ1 and Vδ3 T cells from CMV-infected kidney recipients were able to proliferate in vitro in the presence of free CMV or CMV-infected fibroblast lysates but not uninfected or other herpes virus–infected fibroblast lysates. This in vitro expansion was inhibited by anti-γδ TCR mAb’s. These findings suggest that a population of γδ T cells might play an important role in the immune response of immunosuppressed patients to CMV infection." @default.
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- W2039824458 date "1999-05-15" @default.
- W2039824458 modified "2023-10-18" @default.
- W2039824458 title "Implication of γδ T cells in the human immune response to cytomegalovirus" @default.
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- W2039824458 cites W1535243328 @default.
- W2039824458 cites W1538323547 @default.
- W2039824458 cites W1540974329 @default.
- W2039824458 cites W1565953810 @default.
- W2039824458 cites W1576553969 @default.
- W2039824458 cites W1585900585 @default.
- W2039824458 cites W1896605459 @default.
- W2039824458 cites W190310500 @default.
- W2039824458 cites W1928730528 @default.
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- W2039824458 cites W1972120590 @default.
- W2039824458 cites W1973885793 @default.
- W2039824458 cites W1976601347 @default.
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- W2039824458 cites W1985045544 @default.
- W2039824458 cites W1987815433 @default.
- W2039824458 cites W1988399075 @default.
- W2039824458 cites W1989217948 @default.
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- W2039824458 cites W2018841084 @default.
- W2039824458 cites W2020750867 @default.
- W2039824458 cites W2021106791 @default.
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- W2039824458 cites W2099401468 @default.
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- W2039824458 cites W2109985190 @default.
- W2039824458 cites W2111254069 @default.
- W2039824458 cites W2120042716 @default.
- W2039824458 cites W2134812217 @default.
- W2039824458 cites W2135410703 @default.
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- W2039824458 cites W2149299386 @default.
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- W2039824458 cites W2159024744 @default.
- W2039824458 cites W2313886180 @default.
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- W2039824458 doi "https://doi.org/10.1172/jci5409" @default.
- W2039824458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/408467" @default.
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- W2039824458 hasPublicationYear "1999" @default.
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