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• W2039834569 abstract "Le lupus érythémateux disséminé (LED) est le prototype de la maladie auto-immune systémique. Les cytokines sont des médiateurs solubles permettant létablissement d'interactions entre les différentes populations cellulaires qui composent le système immunitaire d'une part et d'autre part les autres tissus. Ce sont des régulateurs majeurs de la réponse immune normale et constituent un des pivots de la réponse immunitaire pathologique. De ce fait, les cytokines ont été largement étudiées dans les maladies auto-immunes en particulier dans le LED. Dans ce travail, nous nous proposons d'établir une revue critique des connaissances actuelles sur le rôle des cytokines dans le LED. Dans un premier temps, nous nous intéresserons aux rôles des cytokines de type Th1 telles que l'interleukine-2 (IL-2), l'IL-12 et l'interferon-γ (IFN-γ) qui soutiennent l'immunité à médiation cellulaire, et des cytokines de type Th2 (IL-4, IL-6 et IL-10) responsables de l'immunité à médiation humorale. Dans un second temps, nous aborderons des données récentes qui suggèrent que d'autres cytokines, notamment le transforming growth factor-β (TGF-β) et le leukemia inhibitory Factor (LIF), interviennent dans l'immunopathologie du LED. Cytokines in systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is one of the most prevalent systemic autoimmune disorders. Because of their multiple systemic and local effects, cytokines are involved in the skewed immune regulation, inflammation, and tissue damage in SLE. The significance of cytokines in SLE has been largely debated and potential roles of auto-regulatory and inflammatory cytokines have been investigated. Here, we will provide a critical overview of our current knowledge of the roles of the cytokines in SLE. In a first part, we will discuss on the roles of Th1-type cytokines such as interleukin-2 (IL-2), IL-12, and interferon-γ (IFN-γ) which preferentially induce cell-mediated immunity, and Th2-type cytokines, such as IL-4, IL-6 and IL-10 which primarily support antibody production. In a second part, we will focus on recent data suggesting that other cytokines, such as transforming growth factor-β (TGF-β) and leukemia inhibitory factor (LIF), are involved in the immunopathogenesis of lupus." @default.
• W2039834569 created "2016-06-24" @default.
• W2039834569 creator A5031706038 @default.
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• W2039834569 creator A5056713408 @default.
• W2039834569 creator A5075692951 @default.
• W2039834569 date "2000-07-01" @default.
• W2039834569 modified "2023-09-25" @default.
• W2039834569 title "Rôle des cytokines dans la physiopathologie du lupus" @default.
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