FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039841229> ?p ?o ?g. }

• W2039841229 endingPage "111" @default.
• W2039841229 startingPage "104" @default.
• W2039841229 abstract "Activated T lymphocytes are thought to be involved in the pathogenesis of psoriasis. From studies with peripheral blood T lymphocytes it is known that T cells show a decrease in membrane expression of CD27 molecules during continuous antigenic stimulation. The T-cell activation molecule CD28 is thought to be involved in the transduction of an antigen-non-specific costimulatory signal. Therefore, in order to elucidate further the pathogenesis of psoriasis we studied the expression of CD27 and CD28, together with CD4, CD8 and CD45RA in this benign inflammatory dermatological disease. We used immunohistochemical techniques to determine absolute numbers of T lymphocytes and expression of these T-cell activation and T-subset-specific molecules in normal (n = 7), uninvolved perilesional (n = 7) and lesional psoriatic (n = 7) skin. We found that not only lesional but also clinically uninvolved perilesional skin showed an increased number of T cells. Further, immunohistochemical studies showed that CD27 is expressed by a minority of normal skin T cells, while in lesional psoriatic skin, expression was even lower, and almost absent in perilesional skin sections. In contrast to normal skin, both perilesional and lesional psoriatic skin contained no CD28 positive T cells. In lesional psoriatic skin, however, T cells showed predominantly the CD4 phenotype, while in perilesional skin CD8 positive T cells were dominant. Two conclusions were reached: first, the absolute number of T cells, their CD27, CD28 and CD45RA expression, and the influx of CD8 positive T cells, indicate that perilesional psoriatic skin is different from normal and lesional psoriatic skin; and secondly, the data on CD27 and CD28 suggest that not only lesional but also perilesional psoriatic skin is subject to continuous antigenic stimulation, thus leading to decreased CD27 and CD28 expression on skin T cells." @default.
• W2039841229 created "2016-06-24" @default.
• W2039841229 creator A5032410098 @default.
• W2039841229 creator A5035589556 @default.
• W2039841229 creator A5058464811 @default.
• W2039841229 creator A5069044195 @default.
• W2039841229 date "1996-03-01" @default.
• W2039841229 modified "2023-09-27" @default.
• W2039841229 title "Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin" @default.
• W2039841229 cites W1493841666 @default.
• W2039841229 cites W1508333056 @default.
• W2039841229 cites W1572465651 @default.
• W2039841229 cites W1616189793 @default.
• W2039841229 cites W1933255801 @default.
• W2039841229 cites W1968444092 @default.
• W2039841229 cites W1973356939 @default.
• W2039841229 cites W1975913008 @default.
• W2039841229 cites W1989483459 @default.
• W2039841229 cites W1990670919 @default.
• W2039841229 cites W1996462547 @default.
• W2039841229 cites W1999888406 @default.
• W2039841229 cites W2000517438 @default.
• W2039841229 cites W2013150075 @default.
• W2039841229 cites W2029890079 @default.
• W2039841229 cites W2038977682 @default.
• W2039841229 cites W2039536318 @default.
• W2039841229 cites W2040572245 @default.
• W2039841229 cites W2053703609 @default.
• W2039841229 cites W2056503356 @default.
• W2039841229 cites W2057240156 @default.
• W2039841229 cites W2059686909 @default.
• W2039841229 cites W2064358104 @default.
• W2039841229 cites W2073742871 @default.
• W2039841229 cites W2073933243 @default.
• W2039841229 cites W2081454227 @default.
• W2039841229 cites W2090213048 @default.
• W2039841229 cites W2091857813 @default.
• W2039841229 cites W2094474043 @default.
• W2039841229 cites W2147360261 @default.
• W2039841229 cites W2170789806 @default.
• W2039841229 cites W2885719909 @default.
• W2039841229 doi "https://doi.org/10.1046/j.1365-2230.1996.d01-182.x" @default.
• W2039841229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8759195" @default.
• W2039841229 hasPublicationYear "1996" @default.
• W2039841229 type Work @default.
• W2039841229 sameAs 2039841229 @default.
• W2039841229 citedByCount "10" @default.
• W2039841229 countsByYear W20398412292013 @default.
• W2039841229 countsByYear W20398412292020 @default.
• W2039841229 countsByYear W20398412292022 @default.
• W2039841229 crossrefType "journal-article" @default.
• W2039841229 hasAuthorship W2039841229A5032410098 @default.
• W2039841229 hasAuthorship W2039841229A5035589556 @default.
• W2039841229 hasAuthorship W2039841229A5058464811 @default.
• W2039841229 hasAuthorship W2039841229A5069044195 @default.
• W2039841229 hasConcept C142724271 @default.
• W2039841229 hasConcept C147483822 @default.
• W2039841229 hasConcept C148125776 @default.
• W2039841229 hasConcept C167672396 @default.
• W2039841229 hasConcept C203014093 @default.
• W2039841229 hasConcept C204232928 @default.
• W2039841229 hasConcept C2776090121 @default.
• W2039841229 hasConcept C2780564577 @default.
• W2039841229 hasConcept C2780942790 @default.
• W2039841229 hasConcept C71924100 @default.
• W2039841229 hasConcept C8891405 @default.
• W2039841229 hasConceptScore W2039841229C142724271 @default.
• W2039841229 hasConceptScore W2039841229C147483822 @default.
• W2039841229 hasConceptScore W2039841229C148125776 @default.
• W2039841229 hasConceptScore W2039841229C167672396 @default.
• W2039841229 hasConceptScore W2039841229C203014093 @default.
• W2039841229 hasConceptScore W2039841229C204232928 @default.
• W2039841229 hasConceptScore W2039841229C2776090121 @default.
• W2039841229 hasConceptScore W2039841229C2780564577 @default.
• W2039841229 hasConceptScore W2039841229C2780942790 @default.
• W2039841229 hasConceptScore W2039841229C71924100 @default.
• W2039841229 hasConceptScore W2039841229C8891405 @default.
• W2039841229 hasIssue "2" @default.
• W2039841229 hasLocation W20398412291 @default.
• W2039841229 hasLocation W20398412292 @default.
• W2039841229 hasOpenAccess W2039841229 @default.
• W2039841229 hasPrimaryLocation W20398412291 @default.
• W2039841229 hasRelatedWork W1587451388 @default.
• W2039841229 hasRelatedWork W2220102944 @default.
• W2039841229 hasRelatedWork W2350863451 @default.
• W2039841229 hasRelatedWork W2371815043 @default.
• W2039841229 hasRelatedWork W2371888344 @default.
• W2039841229 hasRelatedWork W2409441623 @default.
• W2039841229 hasRelatedWork W3030577180 @default.
• W2039841229 hasRelatedWork W3034007056 @default.
• W2039841229 hasRelatedWork W3213281834 @default.
• W2039841229 hasRelatedWork W4210976760 @default.
• W2039841229 hasVolume "21" @default.
• W2039841229 isParatext "false" @default.
• W2039841229 isRetracted "false" @default.
• W2039841229 magId "2039841229" @default.
• W2039841229 workType "article" @default.