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• W2039843467 abstract "<i>Background:</i> Experimental colitis induces the expression of Na⁺-H⁺ exchanger (NHE) isoforms 1 and 3 in the rat colon, however, their status in rat kidney is not established. <i>Objectives:</i> The renal cortical NHE-1 and -3 expression was examined in the colitic rats. Since cyclooxygenase-2 (cox-2) plays an important role in inflammation, its regulatory role on these isoforms was also investigated by using a cox-2-selective phosphorothioated antisense oligonucleotide (S-oligo). <i>Methods:</i> Male Sprague-Dawley rats having colitis induced by acetic acid or trinitrobenzenesulfonic acid (TNBS) were given injection of S-oligo (3 mg/kg, i.p.) and a mismatched control oligonucleotide (C-oligo) daily 2 h before inducing colitis. Colonic myeloperoxidase activity (MPO) was used to indicate colitis. The renal cortical levels of NHE-1, NHE-3 and α-actin, an internal control, were estimated by the Western blot analysis. <i>Results:</i> Colonic MPO activity was increased and urine output was decreased in both models of colitis. Serum, but not the renal cortical level of TNF-α, was increased in both cases. Only TNBS condition showed an increased PGE₂ level and a decreased body weight. Water intake and renal histology remained unchanged in either case. The NHE-3 protein, localized on the proximal tubules, was increased significantly without any change in NHE-1 and α-actin in both cases. These changes, except the body weight, were significantly reversed by the S-oligo. <i>Conclusions:</i> Selective induction of NHE-3 and TNF-α, and their reversal by cox-2 inhibition, suggest a cox-2-dependent regulation of NHE-3, which possibly involves TNF-α released from the site of inflammation and not from the kidney in colitis. The induction of NHE-3 is independent of the nature of colitides, and might be important to compensate for the loss of electrolyte and water in experimental colitis." @default.
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• W2039843467 date "2002-01-01" @default.
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• W2039843467 title "Antisense Inhibition of Cyclooxygenase-2 Causes a Selective Suppression of the Na⁺-H⁺ Exchanger Isoform 3 in Rat Kidney in Experimental Colitis" @default.
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• W2039843467 doi "https://doi.org/10.1159/000057613" @default.
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