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• W2039844551 abstract "The results of several clinical trials have clearly demonstrated the potential of the anti-idiotype (anti-Id) vaccine abagovomab to induce cancer antigen 125 (CA-125)-specific immunity in ovarian cancer patients. Because of the central role of regulatory T cells (Tregs) in tumor immunology, we analyzed the frequency and suppressive activity of CD25+FoxP3+ Tregs in 16 patients treated with abagovomab. During vaccination, mean frequencies of peripheral Treg with a CD4+CD25+FoxP3+ CD127− phenotype were enhanced but returned to baseline levels in the follow-up phase. Despite increasing Treg counts, the suppressive activity of Tregs was diminished in a subset of patients treated with abagovomab. Reduced Treg activity was associated with increasing polyclonal and CA-125–specific T-cell proliferation in these patients. Interestingly, CA-125–specific T-cell activation could not be further improved by Treg depletion in vitro, as CA-125 induced a suppressive CD4+CD25+FoxP3+ CD127− T cell subset derived from the originally Treg-depleted T-cell fraction. These CA-125–induced Tregs (iTregs) efficiently blocked polyclonal and tumor-specific T-cell activation. Further elimination of iTregs resulted in detectable CA-125–specific T-cell responses in a subset of patients. Based on our results, the suppressive potential rather than the frequency of natural and CA-125–induced Tregs is an important issues to consider for refinement of current anti-Id vaccination." @default.
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• W2039844551 date "2010-01-01" @default.
• W2039844551 modified "2023-10-18" @default.
• W2039844551 title "Suppressive activity rather than frequency of FoxP3+ regulatory T cells is essential for CA-125–specific T-cell activation after abagovomab treatment" @default.
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• W2039844551 doi "https://doi.org/10.1016/j.humimm.2009.09.356" @default.
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