FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039851181> ?p ?o ?g. }

• W2039851181 endingPage "3308" @default.
• W2039851181 startingPage "3303" @default.
• W2039851181 abstract "The mechanism underlying small-for-size graft failure after reperfusion is still unknown. Toll-like receptor 4 (TLR4) has attracted a great deal of attention in inflammation and allograft rejection in recent years. Medicinally, triptolide has anti-inflammatory, immunosuppressive, and antineoplastic activities. In the present study, we studied the effect of triptolide on TLR4 expression in small-for-size grafts.The potential inhibitory effect of triptolide on TLR4 messenger ribonucleic acid and protein in a mouse model of small-for-size liver graft injury was assessed. We also assessed the expression of tumor necrosis factor α and interleukin-6 in this model.The expression of hepatic TLR4 messenger ribonucleic acid and protein and downstream mediators, such as tumor necrosis factor α and interleukin-6, were reduced in the triptolide pretreatment groups (50 and 100 μg) in small-for-size liver grafts. In these same triptolide pretreatment groups, edema and necrosis were reduced and the levels of alanine aminotransferase and aspartate aminotransferase were significantly decreased in these small-for-size liver grafts.This study showed that triptolide might inhibit TLR4 in vivo and that pretreatment with triptolide could inhibit TLR4 activation and reduce small-for-size liver graft injury." @default.
• W2039851181 created "2016-06-24" @default.
• W2039851181 creator A5011805077 @default.
• W2039851181 creator A5017410015 @default.
• W2039851181 creator A5019504710 @default.
• W2039851181 creator A5028698116 @default.
• W2039851181 creator A5034029886 @default.
• W2039851181 creator A5034250958 @default.
• W2039851181 date "2014-12-01" @default.
• W2039851181 modified "2023-10-18" @default.
• W2039851181 title "Triptolide Attenuates Acute Small-for-Size Liver Graft Injury in Rats by Inhibition of Toll-like Receptor 4" @default.
• W2039851181 cites W1574235863 @default.
• W2039851181 cites W1968958068 @default.
• W2039851181 cites W1969426140 @default.
• W2039851181 cites W1978803498 @default.
• W2039851181 cites W1984550366 @default.
• W2039851181 cites W2007514280 @default.
• W2039851181 cites W2013438430 @default.
• W2039851181 cites W2056450083 @default.
• W2039851181 cites W2059427568 @default.
• W2039851181 cites W2068029463 @default.
• W2039851181 cites W2069567259 @default.
• W2039851181 cites W2078738933 @default.
• W2039851181 cites W2079613572 @default.
• W2039851181 cites W2080552152 @default.
• W2039851181 cites W2081630053 @default.
• W2039851181 cites W2084570982 @default.
• W2039851181 cites W2091967759 @default.
• W2039851181 cites W2105899367 @default.
• W2039851181 cites W2112710124 @default.
• W2039851181 cites W2115583388 @default.
• W2039851181 cites W2125113206 @default.
• W2039851181 cites W2137729498 @default.
• W2039851181 cites W2331176038 @default.
• W2039851181 doi "https://doi.org/10.1016/j.transproceed.2014.07.077" @default.
• W2039851181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25498041" @default.
• W2039851181 hasPublicationYear "2014" @default.
• W2039851181 type Work @default.
• W2039851181 sameAs 2039851181 @default.
• W2039851181 citedByCount "8" @default.
• W2039851181 countsByYear W20398511812015 @default.
• W2039851181 countsByYear W20398511812016 @default.
• W2039851181 countsByYear W20398511812017 @default.
• W2039851181 countsByYear W20398511812019 @default.
• W2039851181 countsByYear W20398511812021 @default.
• W2039851181 crossrefType "journal-article" @default.
• W2039851181 hasAuthorship W2039851181A5011805077 @default.
• W2039851181 hasAuthorship W2039851181A5017410015 @default.
• W2039851181 hasAuthorship W2039851181A5019504710 @default.
• W2039851181 hasAuthorship W2039851181A5028698116 @default.
• W2039851181 hasAuthorship W2039851181A5034029886 @default.
• W2039851181 hasAuthorship W2039851181A5034250958 @default.
• W2039851181 hasConcept C126322002 @default.
• W2039851181 hasConcept C164027704 @default.
• W2039851181 hasConcept C170493617 @default.
• W2039851181 hasConcept C17991360 @default.
• W2039851181 hasConcept C190283241 @default.
• W2039851181 hasConcept C203014093 @default.
• W2039851181 hasConcept C2776070231 @default.
• W2039851181 hasConcept C2776637226 @default.
• W2039851181 hasConcept C2776914184 @default.
• W2039851181 hasConcept C2781164371 @default.
• W2039851181 hasConcept C503630168 @default.
• W2039851181 hasConcept C55493867 @default.
• W2039851181 hasConcept C71924100 @default.
• W2039851181 hasConcept C86803240 @default.
• W2039851181 hasConcept C98274493 @default.
• W2039851181 hasConceptScore W2039851181C126322002 @default.
• W2039851181 hasConceptScore W2039851181C164027704 @default.
• W2039851181 hasConceptScore W2039851181C170493617 @default.
• W2039851181 hasConceptScore W2039851181C17991360 @default.
• W2039851181 hasConceptScore W2039851181C190283241 @default.
• W2039851181 hasConceptScore W2039851181C203014093 @default.
• W2039851181 hasConceptScore W2039851181C2776070231 @default.
• W2039851181 hasConceptScore W2039851181C2776637226 @default.
• W2039851181 hasConceptScore W2039851181C2776914184 @default.
• W2039851181 hasConceptScore W2039851181C2781164371 @default.
• W2039851181 hasConceptScore W2039851181C503630168 @default.
• W2039851181 hasConceptScore W2039851181C55493867 @default.
• W2039851181 hasConceptScore W2039851181C71924100 @default.
• W2039851181 hasConceptScore W2039851181C86803240 @default.
• W2039851181 hasConceptScore W2039851181C98274493 @default.
• W2039851181 hasFunder F4320321001 @default.
• W2039851181 hasIssue "10" @default.
• W2039851181 hasLocation W20398511811 @default.
• W2039851181 hasLocation W20398511812 @default.
• W2039851181 hasOpenAccess W2039851181 @default.
• W2039851181 hasPrimaryLocation W20398511811 @default.
• W2039851181 hasRelatedWork W1513368991 @default.
• W2039851181 hasRelatedWork W1984305258 @default.
• W2039851181 hasRelatedWork W2078378773 @default.
• W2039851181 hasRelatedWork W2127335531 @default.
• W2039851181 hasRelatedWork W2136469540 @default.
• W2039851181 hasRelatedWork W2165578318 @default.
• W2039851181 hasRelatedWork W2324261047 @default.
• W2039851181 hasRelatedWork W2403366498 @default.
• W2039851181 hasRelatedWork W4224862991 @default.
• W2039851181 hasRelatedWork W4311939469 @default.

• next