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• W2039857027 abstract "Chloramphenicol (CAP), when given prior to CCl4, prevented the CCl4-induced liver necrosis observed at either 24 or 72 hr after its administration. CAP administration did not modify either body temperature of the CCl4-treated rats or the CCl4 levels in the liver at different times after CCl4 administration. Prior treatment of the rats with CAP decreased the extent of irreversible binding of 14CCl4 to liver microsomal lipids, reduced CCl4-induced lipid peroxidation, decreased CCl4-induced polysome breakdown, and attenuated the dilation and vesiculation of the endoplasmic reticulum induced by CCl4. The results are analyzed in relation to the hypothesis that drug-metabolizing enzymes and activation of CCl4 are related to its hepatotoxic effects." @default.
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• W2039857027 date "1978-06-01" @default.
• W2039857027 modified "2023-09-25" @default.
• W2039857027 title "Mechanism of chloramphenicol prevention of carbon tetrachloride-induced liver damage" @default.
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• W2039857027 doi "https://doi.org/10.1016/0014-4800(78)90013-8" @default.
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