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- W2039859631 abstract "Zinc is one of the metal ions essential for life, as it is required for the proper functioning of a large number of proteins. Despite its importance, the annotation of zinc-binding proteins in gene banks or protein domain databases still has significant room for improvement. In the present work, we compiled a list of known zinc-binding protein domains and of known zinc-binding sequence motifs (zinc-binding patterns), and then used them jointly to analyze the proteome of 57 different organisms to obtain an overview of zinc usage by archaeal, bacterial, and eukaryotic organisms. Zinc-binding proteins are an abundant fraction of these proteomes, ranging between 4% and 10%. The number of zinc-binding proteins correlates linearly with the total number of proteins encoded by the genome of an organism, but the proportionality constant of Eukaryota (8.8%) is significantly higher than that observed in Bacteria and Archaea (from 5% to 6%). Most of this enrichment is due to the larger portfolio of regulatory proteins in Eukaryota. Keywords: Zinc • metalloproteins • gene expression • zinc fingers" @default.
- W2039859631 created "2016-06-24" @default.
- W2039859631 creator A5016319366 @default.
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- W2039859631 date "2006-10-19" @default.
- W2039859631 modified "2023-10-11" @default.
- W2039859631 title "Zinc through the Three Domains of Life" @default.
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- W2039859631 doi "https://doi.org/10.1021/pr0603699" @default.
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