FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039859863> ?p ?o ?g. }

• W2039859863 endingPage "428" @default.
• W2039859863 startingPage "417" @default.
• W2039859863 abstract "The mRNA encoding the β-subunit of the mitochondrial H+-ATP synthase (β-F1-ATPase) is localized in an approx. 150nm structure of the hepatocyte of mammals. In the present study, we have investigated the cis- and trans-acting factors involved in the generation of the ribonucleoprotein complex containing β-F1-ATPase mRNA. Two cis-acting elements (β1.2 and 3′β) have been identified. The β1.2 element is placed in the open reading frame, downstream of the region encoding the mitochondrial pre-sequence of the protein. The 3′β element is the 3′ non-translated region of the mRNA. Complex sets of proteins from the soluble and non-soluble fractions of the liver interact with the β1.2 and 3′β elements. A soluble p88, present also in reticulocyte lysate, displays binding specificity for both the cis-acting elements. Sedimentation and high-resolution in situ hybridization experiments showed that the structure containing the rat liver β-F1-ATPase mRNA is found in fractions of high sucrose concentration, where large polysomes sediment. Treatment of liver extracts with EDTA promoted the mobilization of β-F1-ATPase mRNA to fractions of lower sucrose concentration, suggesting that the structure containing β-F1-ATPase mRNA is a large polysome. Finally, in vitro reconstitution experiments with reticulocyte lysate, using either the full-length, mutant or chimaeric versions of β-F1-ATPase mRNA, reveal that the assembly of the β-F1-ATPase mRNA polysome requires the co-operation of both the cis-acting mRNA determinants. The present study illustrates the existence of an intramolecular RNA cross-talking required for the association of the mRNA with the translational machinery." @default.
• W2039859863 created "2016-06-24" @default.
• W2039859863 creator A5019704720 @default.
• W2039859863 creator A5050723897 @default.
• W2039859863 creator A5082642974 @default.
• W2039859863 creator A5089602538 @default.
• W2039859863 date "2002-07-15" @default.
• W2039859863 modified "2023-09-25" @default.
• W2039859863 title "Assembly of the ribonucleoprotein complex containing the mRNA of the β-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins" @default.
• W2039859863 cites W1493498138 @default.
• W2039859863 cites W1502506716 @default.
• W2039859863 cites W1524879891 @default.
• W2039859863 cites W1528061714 @default.
• W2039859863 cites W1535983677 @default.
• W2039859863 cites W1540954091 @default.
• W2039859863 cites W1545736837 @default.
• W2039859863 cites W1593737978 @default.
• W2039859863 cites W1675105927 @default.
• W2039859863 cites W1935078181 @default.
• W2039859863 cites W1964976203 @default.
• W2039859863 cites W1973910583 @default.
• W2039859863 cites W1976365049 @default.
• W2039859863 cites W1977760730 @default.
• W2039859863 cites W1986461283 @default.
• W2039859863 cites W1995652680 @default.
• W2039859863 cites W1996243796 @default.
• W2039859863 cites W2002311094 @default.
• W2039859863 cites W2004790224 @default.
• W2039859863 cites W2016652535 @default.
• W2039859863 cites W2018026783 @default.
• W2039859863 cites W2028858498 @default.
• W2039859863 cites W2031847747 @default.
• W2039859863 cites W2035312521 @default.
• W2039859863 cites W2041306659 @default.
• W2039859863 cites W2041882874 @default.
• W2039859863 cites W2043886388 @default.
• W2039859863 cites W2044895959 @default.
• W2039859863 cites W2049758752 @default.
• W2039859863 cites W2077415858 @default.
• W2039859863 cites W2092453365 @default.
• W2039859863 cites W2093716479 @default.
• W2039859863 cites W2096012822 @default.
• W2039859863 cites W2097617128 @default.
• W2039859863 cites W2098329869 @default.
• W2039859863 cites W2101060338 @default.
• W2039859863 cites W2102715482 @default.
• W2039859863 cites W2102883851 @default.
• W2039859863 cites W2103816676 @default.
• W2039859863 cites W2105322114 @default.
• W2039859863 cites W2107777962 @default.
• W2039859863 cites W2108065149 @default.
• W2039859863 cites W2116438422 @default.
• W2039859863 cites W2118176159 @default.
• W2039859863 cites W2123174499 @default.
• W2039859863 cites W2140920105 @default.
• W2039859863 cites W2142374550 @default.
• W2039859863 cites W2150064925 @default.
• W2039859863 cites W2154823420 @default.
• W2039859863 cites W2157723478 @default.
• W2039859863 cites W2158502531 @default.
• W2039859863 cites W2158951373 @default.
• W2039859863 cites W2162592749 @default.
• W2039859863 cites W2169232755 @default.
• W2039859863 cites W2171462241 @default.
• W2039859863 cites W2331779442 @default.
• W2039859863 cites W233265278 @default.
• W2039859863 cites W259468590 @default.
• W2039859863 doi "https://doi.org/10.1042/bj20011726" @default.
• W2039859863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1222693" @default.
• W2039859863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11952427" @default.
• W2039859863 hasPublicationYear "2002" @default.
• W2039859863 type Work @default.
• W2039859863 sameAs 2039859863 @default.
• W2039859863 citedByCount "25" @default.
• W2039859863 countsByYear W20398598632012 @default.
• W2039859863 countsByYear W20398598632015 @default.
• W2039859863 countsByYear W20398598632019 @default.
• W2039859863 countsByYear W20398598632020 @default.
• W2039859863 countsByYear W20398598632022 @default.
• W2039859863 crossrefType "journal-article" @default.
• W2039859863 hasAuthorship W2039859863A5019704720 @default.
• W2039859863 hasAuthorship W2039859863A5050723897 @default.
• W2039859863 hasAuthorship W2039859863A5082642974 @default.
• W2039859863 hasAuthorship W2039859863A5089602538 @default.
• W2039859863 hasBestOaLocation W20398598632 @default.
• W2039859863 hasConcept C104292427 @default.
• W2039859863 hasConcept C104317684 @default.
• W2039859863 hasConcept C105580179 @default.
• W2039859863 hasConcept C153911025 @default.
• W2039859863 hasConcept C181199279 @default.
• W2039859863 hasConcept C23265538 @default.
• W2039859863 hasConcept C2778403015 @default.
• W2039859863 hasConcept C55493867 @default.
• W2039859863 hasConcept C65666806 @default.
• W2039859863 hasConcept C67705224 @default.
• W2039859863 hasConcept C75934600 @default.
• W2039859863 hasConcept C86803240 @default.
• W2039859863 hasConcept C88478588 @default.

• next