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- W2039873005 abstract "Publisher Summary This chapter discusses amino acid-derived peptide mimetics corresponding to exposed protein epitopes, such as β-turns, loops, 3 10 -helical and or-helical structures, which serves as valuable tools to probe potential ligand-receptor or ligand-enzyme interaction sites. The chapter presents the ideas as to how such structural knowledge may be transferred to small non-peptidic molecules, using parallel and combinatorial chemistry. After a target protein has been identified and selected, it is expressed and purified using modern biochemical techniques. Once the material is available in pure form and sufficient quantity, the phases of structure determination and assay development usually start simultaneously. The assay is subsequently transferred into a format suitable for high-throughput screening, whereupon the process of screening a large number of structurally diverse compounds is initiated. The selection of these compound collections is usually performed in a random fashion, or by using 2D- and 3D-clustering techniques. Once a ligand molecule has been identified in the screening process, it can serve as a starting point for lead optimization and/or, in case crystals of the target protein are available, be co-crystallized with the protein." @default.
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- W2039873005 date "2010-06-13" @default.
- W2039873005 modified "2023-09-28" @default.
- W2039873005 title "ChemInform Abstract: Novel Peptide Mimetic Building Blocks and Strategies for Efficient Lead Finding" @default.
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- W2039873005 doi "https://doi.org/10.1002/chin.199937301" @default.
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