FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039892005> ?p ?o ?g. }

• W2039892005 endingPage "202" @default.
• W2039892005 startingPage "196" @default.
• W2039892005 abstract "In order to understand relationships between executive and structural deficits in the frontal cortex of patients within normal aging or Alzheimer's disease, we studied frontal pathological changes in young and old controls compared to cases with sporadic (AD) or familial Alzheimer's disease (FAD). We performed a semi-automatic computer assisted analysis of the distribution of β-amyloid (Aβ) deposits revealed by Aβ immunostaining as well as of neurofibrillary tangles (NFT) revealed by Gallyas silver staining in Brodman areas 10 (frontal polar), 12 (ventro-infero-median) and 24 (anterior cingular), using tissue samples from 5 FAD, 6 sporadic AD and 10 control brains. We also performed densitometric measurements of glial fibrillary acidic protein, principal compound of intermediate filaments of astrocytes, and of phosphorylated neurofilament H and M epitopes in areas 10 and 24. All regions studied seem almost completely spared in normal old controls, with only the oldest ones exhibiting a weak percentage of β-amyloid deposit and hardly any NFT. On the contrary, all AD and FAD cases were severely damaged as shown by statistically significant increased percentages of β-amyloid deposit, as well as by a high number of NFT. FAD cases (all from the same family) had statistically more β-amyloid and GFAP than sporadic AD cases in both areas 10 and 24 and statistically more NFT only in area 24. The correlation between the percentage of β-amyloid and the number of NFT was significant only for area 24. Altogether, these data suggest that the frontal cortex can be spared by AD type lesions in normal aging, but is severely damaged in sporadic and still more in familial Alzheimer's disease. The frontal regions appear to be differentially vulnerable, with area 12 having the less amyloid burden, area 24 the less NFT and area 10 having both more amyloid and more NFT. This pattern of damage in frontal regions may represent a strong neuroanatomical support for the deterioration of attention and cognitive capacities as well as for the presence of emotional and behavioral troubles in AD patients." @default.
• W2039892005 created "2016-06-24" @default.
• W2039892005 creator A5008412608 @default.
• W2039892005 creator A5019887498 @default.
• W2039892005 creator A5053024818 @default.
• W2039892005 creator A5057626488 @default.
• W2039892005 creator A5062790459 @default.
• W2039892005 creator A5076233059 @default.
• W2039892005 date "2009-10-01" @default.
• W2039892005 modified "2023-10-14" @default.
• W2039892005 title "Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease" @default.
• W2039892005 cites W1654885769 @default.
• W2039892005 cites W1965407459 @default.
• W2039892005 cites W1970807381 @default.
• W2039892005 cites W1973267026 @default.
• W2039892005 cites W1973963820 @default.
• W2039892005 cites W1980794267 @default.
• W2039892005 cites W1983230739 @default.
• W2039892005 cites W1984009511 @default.
• W2039892005 cites W1988764534 @default.
• W2039892005 cites W1990379890 @default.
• W2039892005 cites W1990468088 @default.
• W2039892005 cites W1995810302 @default.
• W2039892005 cites W2000706612 @default.
• W2039892005 cites W2003061822 @default.
• W2039892005 cites W2005626110 @default.
• W2039892005 cites W2008337653 @default.
• W2039892005 cites W2013535631 @default.
• W2039892005 cites W2013869842 @default.
• W2039892005 cites W2023081620 @default.
• W2039892005 cites W2048623403 @default.
• W2039892005 cites W2050006425 @default.
• W2039892005 cites W2052537066 @default.
• W2039892005 cites W2066792703 @default.
• W2039892005 cites W2073688368 @default.
• W2039892005 cites W2074424606 @default.
• W2039892005 cites W2076173615 @default.
• W2039892005 cites W2078790263 @default.
• W2039892005 cites W2080208818 @default.
• W2039892005 cites W2085602123 @default.
• W2039892005 cites W2091004265 @default.
• W2039892005 cites W2094675227 @default.
• W2039892005 cites W2109862162 @default.
• W2039892005 cites W2113197827 @default.
• W2039892005 cites W2115789347 @default.
• W2039892005 cites W2122318491 @default.
• W2039892005 cites W2125823313 @default.
• W2039892005 cites W2140425743 @default.
• W2039892005 cites W2141466480 @default.
• W2039892005 cites W2155347619 @default.
• W2039892005 cites W2159916470 @default.
• W2039892005 cites W2162812585 @default.
• W2039892005 cites W2170656454 @default.
• W2039892005 cites W2171231804 @default.
• W2039892005 cites W2209078744 @default.
• W2039892005 cites W2473401668 @default.
• W2039892005 cites W2620659939 @default.
• W2039892005 cites W4246009434 @default.
• W2039892005 cites W4253732983 @default.
• W2039892005 cites W4376848492 @default.
• W2039892005 cites W4379089834 @default.
• W2039892005 cites W2182295191 @default.
• W2039892005 doi "https://doi.org/10.1016/j.brainresbull.2009.06.009" @default.
• W2039892005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19559767" @default.
• W2039892005 hasPublicationYear "2009" @default.
• W2039892005 type Work @default.
• W2039892005 sameAs 2039892005 @default.
• W2039892005 citedByCount "15" @default.
• W2039892005 countsByYear W20398920052012 @default.
• W2039892005 countsByYear W20398920052013 @default.
• W2039892005 countsByYear W20398920052014 @default.
• W2039892005 countsByYear W20398920052015 @default.
• W2039892005 countsByYear W20398920052017 @default.
• W2039892005 countsByYear W20398920052021 @default.
• W2039892005 countsByYear W20398920052022 @default.
• W2039892005 crossrefType "journal-article" @default.
• W2039892005 hasAuthorship W2039892005A5008412608 @default.
• W2039892005 hasAuthorship W2039892005A5019887498 @default.
• W2039892005 hasAuthorship W2039892005A5053024818 @default.
• W2039892005 hasAuthorship W2039892005A5057626488 @default.
• W2039892005 hasAuthorship W2039892005A5062790459 @default.
• W2039892005 hasAuthorship W2039892005A5076233059 @default.
• W2039892005 hasConcept C142724271 @default.
• W2039892005 hasConcept C157207234 @default.
• W2039892005 hasConcept C169760540 @default.
• W2039892005 hasConcept C204232928 @default.
• W2039892005 hasConcept C207886595 @default.
• W2039892005 hasConcept C2777127467 @default.
• W2039892005 hasConcept C2777348757 @default.
• W2039892005 hasConcept C2777427615 @default.
• W2039892005 hasConcept C2777633098 @default.
• W2039892005 hasConcept C2778670691 @default.
• W2039892005 hasConcept C2779134260 @default.
• W2039892005 hasConcept C2779721402 @default.
• W2039892005 hasConcept C2780495277 @default.
• W2039892005 hasConcept C2993858690 @default.
• W2039892005 hasConcept C4224716 @default.
• W2039892005 hasConcept C502032728 @default.

• next