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- W2039894764 abstract "The metabolites of beraprost sodium in plasma and tissues, and its biliary excretion and enterohepatic circulation were investigated in male and female rats using 3H-labelled substance.The most predominant metabolite, 2, 3-dinor-beraprost was shown to be distributed mainly in the liver. However, this β-oxidation metabolite was found to be produced in male rats at an apparently higher level than in female rats. On the other hand, as the oxidation of C-15 alcohol is concerned, the females possess higher capacity for this biotransformation process. The study on biliary excretion showed that male rats could excrete more drug, principally as 2, 3-dinor-beraprost, into the bile compared to the female rats. This sex difference in biliary excretion was facilitated by the following enterohepatic circulation. As a result, urinary excretion of beraprost sodium in female rats attained nearly four times of that in male rats.All these results seem to be basically related to the difference in β-oxidation capacity in the liver of both sexes." @default.
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- W2039894764 date "1989-01-01" @default.
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- W2039894764 title "Pharmacokinetics and biotransformation of beraprost sodium. III. Metabolites in tissues and enterohepatic circulation of beraprost sodium in rat." @default.
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- W2039894764 doi "https://doi.org/10.2133/dmpk.4.743" @default.
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