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- W2039896955 abstract "After the administration of p-hydroxyamphetamine 20 mg/kg intraperitoneally, there was a 50 per cent decrease in the brain noradrenaline (NA) level and a 70 per cent decrease in the heart NA level at 4–8 hours after the injection. Control levels of brain and heart NA were reached at 96–144 hours after a single dose of the drug. Repeated injections of p-hydroxyamphetamine, 20 mg/kg twice daily for 3 days, caused a depletion of brain and heart NA to about 20 per cent of the control levels. The brain dopamine (DA) level was reduced to 85 per cent of the control level at 1 hour after 20 mg/kg of the drug and to 76 per cent after 40 mg/kg. After the repeated injections of p-OH-A, the brain DA was reduced to 70 per cent of the control level. Radioactively labelled p-hydroxynorephedrine was isolated from both brain and heart tissue extracts after the administration of p-hydroxyamphetamine-3H. Parahydroxynorephedrine-3H remained in the brain and the heart as long as the NA levels were decreased. The NA deficit in the brain and heart corresponded approximately to the amounts of p-hydroxynorephedrine-3H present in the tissues. In reserpine pretreated rats the amounts of p-hydroxynorephedrine-3H formed in the brain and heart tissues were reduced, indicating that p-hydroxynorephedrine is bound by a reserpine sensitive storage mechanism. Administration of p-hydroxyamphetamine or amphetamine accelerated the disappearance of labelled p-hydroxynorephedrine from the brain and the heart." @default.
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- W2039896955 date "2009-03-13" @default.
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- W2039896955 title "Displacement of Brain and Heart Noradrenaline by p-Hydroxynorephedrine after Administration of p-Hydroxyamphetamine" @default.
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- W2039896955 doi "https://doi.org/10.1111/j.1600-0773.1971.tb00579.x" @default.
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