Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039899392> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2039899392 endingPage "352" @default.
- W2039899392 startingPage "347" @default.
- W2039899392 abstract "OBJECTIVES To define the effect of GnRH agonist (GnRHa) treatment on endothelial nitric oxide synthase (eNOS) expression in leiomyoma. As eNOS expression is more pronounced in leiomyoma compared to parental myometrium, we hypothesized that the mechanism(s) of tumor shrinkage by GnRHa may be due to decreased nitric oxide (NO) production in leiomyoma.Eleven patients with leiomyoma were operated for myoma enucleation by laparatomy. Six of them were treated with GnRHa every 28 days, three times before the operation. The remaining five patients who had no treatment prior to operation formed the control group. Blood was drawn from the patients before treatment and on the day of operation for the assay of serum estradiol (E(2)). Immunohistochemical localization of eNOS expression in leiomyoma and myometrium in treated patients, and in leiomyoma in the control group, was performed using monoclonal antibodies specific to eNOS.All treated subjects showed a significant reduction of fibroid volume at the end of therapy. eNOS-positive cells were localized primarily within the vascular endothelium and smooth muscle cells, but had weak expression in fibroid and myometrial muscle cells in the treated group. The immunoreactivity was similar for both the leiomyoma and myometrium (P > 0.05). In contrast to this, the control group had shown strong expression in leiomyoma muscle cells (P < 0.005) in addition to the vascular endothelium and smooth muscle cells.GnRHa-induced tumor shrinkage should be due to diminished eNOS expression, most probably by lowering estrogen secretion." @default.
- W2039899392 created "2016-06-24" @default.
- W2039899392 creator A5007262340 @default.
- W2039899392 creator A5073152432 @default.
- W2039899392 creator A5073618525 @default.
- W2039899392 creator A5080835509 @default.
- W2039899392 date "2000-08-25" @default.
- W2039899392 modified "2023-10-05" @default.
- W2039899392 title "GnRH agonist decreases endothelial nitric oxide synthase (eNOS) expression in leiomyoma" @default.
- W2039899392 cites W1913675875 @default.
- W2039899392 cites W1994190175 @default.
- W2039899392 cites W2001946752 @default.
- W2039899392 cites W2008482216 @default.
- W2039899392 cites W2014736171 @default.
- W2039899392 cites W2014994159 @default.
- W2039899392 cites W2015767866 @default.
- W2039899392 cites W2017331982 @default.
- W2039899392 cites W2018689859 @default.
- W2039899392 cites W2031594566 @default.
- W2039899392 cites W2033941875 @default.
- W2039899392 cites W2043193228 @default.
- W2039899392 cites W2053483186 @default.
- W2039899392 cites W2067911223 @default.
- W2039899392 cites W2071289624 @default.
- W2039899392 cites W2072683660 @default.
- W2039899392 cites W2079880074 @default.
- W2039899392 cites W2095350264 @default.
- W2039899392 cites W2414394097 @default.
- W2039899392 cites W4247062919 @default.
- W2039899392 doi "https://doi.org/10.1016/s0020-7292(00)00198-3" @default.
- W2039899392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10967169" @default.
- W2039899392 hasPublicationYear "2000" @default.
- W2039899392 type Work @default.
- W2039899392 sameAs 2039899392 @default.
- W2039899392 citedByCount "11" @default.
- W2039899392 countsByYear W20398993922012 @default.
- W2039899392 countsByYear W20398993922016 @default.
- W2039899392 countsByYear W20398993922020 @default.
- W2039899392 crossrefType "journal-article" @default.
- W2039899392 hasAuthorship W2039899392A5007262340 @default.
- W2039899392 hasAuthorship W2039899392A5073152432 @default.
- W2039899392 hasAuthorship W2039899392A5073618525 @default.
- W2039899392 hasAuthorship W2039899392A5080835509 @default.
- W2039899392 hasConcept C126322002 @default.
- W2039899392 hasConcept C134018914 @default.
- W2039899392 hasConcept C142724271 @default.
- W2039899392 hasConcept C2777622882 @default.
- W2039899392 hasConcept C2777795800 @default.
- W2039899392 hasConcept C2778164554 @default.
- W2039899392 hasConcept C2778326061 @default.
- W2039899392 hasConcept C2779066055 @default.
- W2039899392 hasConcept C2779395532 @default.
- W2039899392 hasConcept C2992686903 @default.
- W2039899392 hasConcept C3017725331 @default.
- W2039899392 hasConcept C519581460 @default.
- W2039899392 hasConcept C71924100 @default.
- W2039899392 hasConceptScore W2039899392C126322002 @default.
- W2039899392 hasConceptScore W2039899392C134018914 @default.
- W2039899392 hasConceptScore W2039899392C142724271 @default.
- W2039899392 hasConceptScore W2039899392C2777622882 @default.
- W2039899392 hasConceptScore W2039899392C2777795800 @default.
- W2039899392 hasConceptScore W2039899392C2778164554 @default.
- W2039899392 hasConceptScore W2039899392C2778326061 @default.
- W2039899392 hasConceptScore W2039899392C2779066055 @default.
- W2039899392 hasConceptScore W2039899392C2779395532 @default.
- W2039899392 hasConceptScore W2039899392C2992686903 @default.
- W2039899392 hasConceptScore W2039899392C3017725331 @default.
- W2039899392 hasConceptScore W2039899392C519581460 @default.
- W2039899392 hasConceptScore W2039899392C71924100 @default.
- W2039899392 hasIssue "3" @default.
- W2039899392 hasLocation W20398993921 @default.
- W2039899392 hasLocation W20398993922 @default.
- W2039899392 hasOpenAccess W2039899392 @default.
- W2039899392 hasPrimaryLocation W20398993921 @default.
- W2039899392 hasRelatedWork W1562919697 @default.
- W2039899392 hasRelatedWork W2038075731 @default.
- W2039899392 hasRelatedWork W2039899392 @default.
- W2039899392 hasRelatedWork W2099366831 @default.
- W2039899392 hasRelatedWork W2240063833 @default.
- W2039899392 hasRelatedWork W2358871021 @default.
- W2039899392 hasRelatedWork W2360518732 @default.
- W2039899392 hasRelatedWork W2369345345 @default.
- W2039899392 hasRelatedWork W2389377539 @default.
- W2039899392 hasRelatedWork W3194150676 @default.
- W2039899392 hasVolume "70" @default.
- W2039899392 isParatext "false" @default.
- W2039899392 isRetracted "false" @default.
- W2039899392 magId "2039899392" @default.
- W2039899392 workType "article" @default.