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- W2039904107 abstract "From the Mayo Clinic and Mayo Foundation, Rochester, MN. Address reprint requests to Teresa S.M. Tsang, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail: tsang.teresa@mayo.edu 0033-0620/$ see front matter n 2005 Elsevier Inc. All rights reserved. doi:10.1016/j.pcad.2005.06.001 A trial fibrillation (AF) is primarily, but not exclusively, a disease of older people. With progressively greater number of people living to an older age, the magnitude of this public health problem is continuously increasing. The lifetime risk for AF is 1:4 for men and women older than 40 years. The prevalence of this condition in the United States has been reported to be 2.3 million and is projected to increase to 5.6 million by 2050. Based on National Hospital Discharge Survey, AF-related hospitalization increased by almost 3-fold between 1985 and 1999. This trend continued after the 1990s, with a relative increase in admissions for AF by 34% in 1996 to 2001. The trends of increased prevalence and resource use show no signs of abating. Considering that AF can be paroxysmal and not detected for some time, and that AF may be asymptomatic and remain undiagnosed altogether, the published estimations likely represent only a part of the total burden. AF in older individuals is frequently accompanied by other age-related conditions. The clinical sequelae are multiple, including congestive heart failure (CHF), stroke, and premature death. It has also been linked to cognitive dysfunction, although this remains unproven. AF in older persons generally does not occur in isolation but within the context of other agerelated cardiovascular conditions (hypertension, coronary artery disease, diabetes, and heart failure), pulmonary diseases, and chronic or even preterminal illnesses. AF in this clinical setting appears to have developed secondary to left atrial and/or pulmonary venous structural and electrical remodeling in response to systemic inflammation, cardiovascular, and hemodynamic stresses. Much less commonly, AF occurs in the absence of overt cardiac structural abnormalities, conventionally referred to as blone AF, Q -21 which more frequently occurs in younger persons" @default.
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- W2039904107 date "2005-07-01" @default.
- W2039904107 modified "2023-09-25" @default.
- W2039904107 title "Epidemiological Profile of Atrial Fibrillation: A Contemporary Perspective" @default.
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- W2039904107 doi "https://doi.org/10.1016/j.pcad.2005.06.001" @default.
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