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- W2039915229 abstract "The objective of this study was to determine if UK 38,485, a thromboxane synthetase inhibitor (TSI), would prolong survival and attenuate acute lung injury (ALI) in rat endotoxemia. 24 mechanically ventilated rats received 10 mg/kg E. coli LPS. 12 rats received 5 mg/kg TSI, 1 hr prior to LPS infusion. Heart rate, BP, ABG and lactate levels were measured at 0, 30, 60, 90, 120 min. 2 hrs after LPS or at the time of death, alveolar macrophages were collected, washed and resuspended in media. A baseline and 24 hr incubated supernatant were collected for TX, nitric oxide (NO), and PGE2. Rats pretreated with TSI survived longer (117± 3 vs 92± 11 min, p<0.03) and at 30 min had less A-a gradient (247±30 vs 383±44 torr, p<0.01), and acidosis (pH 7.33±.02 vs 7.27±03, p<0.005). No differences in BP, HR, or lactate were observed between the 2 groups. The alveolar macrophages of rats receiving TSI produced more NO at baseline, (fig). Although TX production was inhibited in the plasma of TSI treated endotoxemic rats, the alveolar macrophages continued to produce TX in quantities similar to rats receiving LPS alone,(1000±22 vs 873±223 pg/ml). PGE2 was similar in both groups. Conclusions: TSI prolongs survival in acute endotoxemia by decreasing ALI. The lung protection by TSI appears secondary to an increased production of NO by alveolar macrophages rather than decreased pulmonary TX synthesis." @default.
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- W2039915229 date "1997-04-01" @default.
- W2039915229 modified "2023-09-26" @default.
- W2039915229 title "BENEFICIAL EFFECTS OF A THROMBOXANE SYNTHETASE INHIBITOR (UK 38,485) IN RAT ENDOTOXEMIA. 189" @default.
- W2039915229 doi "https://doi.org/10.1203/00006450-199704001-00209" @default.
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