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- W2039916074 abstract "Obvious immunological defects are generally not a problem in cancer patients at the time of diagnosis: immunological depression, when it appears, sets in progressively and is proportional to the extent of the neoplasm. A generalised decrease in immunological surveillance cannot, therefore, explain why cancer does arise in a previously healthy person. A large body of evidence points towards the fact that each individual shows a genetically predetermined unresponsiveness to a large number of antigens. It is possible, therefore, that clinical malignancy only appears when malignant clones of cells have tumour-antigen determinants for which the immunological apparatus of that particular individual is genetically not programmed to react efficiently—in other words, when there is a partial or total selective immune unresponsiveness to tumour antigens." @default.
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- W2039916074 date "1973-03-01" @default.
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- W2039916074 title "CANCER CAUSED BY AN INHERITED SELECTIVE DEFECT IN IMMUNOLOGICAL SURVEILLANCE" @default.
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- W2039916074 doi "https://doi.org/10.1016/s0140-6736(73)92203-4" @default.
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