Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039921189> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2039921189 endingPage "454" @default.
- W2039921189 startingPage "445" @default.
- W2039921189 abstract "Recent studies have suggested that prostaglandin (PG) E2 (PGE2) and the prostaglandin pathway are essential for hematopoietic stem cell growth and development. However, similar studies on hematopoietic commitment from human embryonic stem cells (hESCs) are still limited. Here we report that the addition of PGE2 promotes hematopoietic differentiation of hESCs. The induced cells from hESCs/OP9 co-culture and in the presence of PGE2 were characterized by reverse transcription-PCR (RT-PCR), flow cytometry, colony-forming assays and Wright-Giemsa staining. Our results demonstrated that PGE2 exposure could alter the gene expression pattern and morphology of co-cultured hESCs and resulted in a robust hematopoietic differentiation with higher frequencies of CD34+ and CD45+ cells. Furthermore, the Smad signaling pathway may be involved in PGE2 and OP9 induced hematopoietic differentiation of hESCs. This research may improve our knowledge of stem cell regulation and hopefully lead to better stem cell-based therapeutic options." @default.
- W2039921189 created "2016-06-24" @default.
- W2039921189 creator A5005882994 @default.
- W2039921189 creator A5013628889 @default.
- W2039921189 creator A5015263816 @default.
- W2039921189 creator A5020374246 @default.
- W2039921189 creator A5020490445 @default.
- W2039921189 creator A5023327838 @default.
- W2039921189 creator A5033816238 @default.
- W2039921189 creator A5070685116 @default.
- W2039921189 creator A5073554386 @default.
- W2039921189 creator A5077724687 @default.
- W2039921189 date "2010-10-01" @default.
- W2039921189 modified "2023-10-16" @default.
- W2039921189 title "Prostaglandin E2 promotes hematopoietic development from human embryonic stem cells" @default.
- W2039921189 cites W1606473945 @default.
- W2039921189 cites W1972124518 @default.
- W2039921189 cites W1990767607 @default.
- W2039921189 cites W1992838550 @default.
- W2039921189 cites W2001476006 @default.
- W2039921189 cites W2003589118 @default.
- W2039921189 cites W2004340720 @default.
- W2039921189 cites W2008995006 @default.
- W2039921189 cites W2018192635 @default.
- W2039921189 cites W2019244424 @default.
- W2039921189 cites W2024713922 @default.
- W2039921189 cites W2029203471 @default.
- W2039921189 cites W2032162774 @default.
- W2039921189 cites W2035275095 @default.
- W2039921189 cites W2037862743 @default.
- W2039921189 cites W2046193560 @default.
- W2039921189 cites W2048107295 @default.
- W2039921189 cites W2050376918 @default.
- W2039921189 cites W2071890540 @default.
- W2039921189 cites W2072200539 @default.
- W2039921189 cites W2075469935 @default.
- W2039921189 cites W2077999704 @default.
- W2039921189 cites W2085047561 @default.
- W2039921189 cites W2087175325 @default.
- W2039921189 cites W2107176747 @default.
- W2039921189 cites W2126853519 @default.
- W2039921189 cites W2140717627 @default.
- W2039921189 cites W2155062057 @default.
- W2039921189 doi "https://doi.org/10.1007/s11515-010-0810-2" @default.
- W2039921189 hasPublicationYear "2010" @default.
- W2039921189 type Work @default.
- W2039921189 sameAs 2039921189 @default.
- W2039921189 citedByCount "1" @default.
- W2039921189 countsByYear W20399211892018 @default.
- W2039921189 crossrefType "journal-article" @default.
- W2039921189 hasAuthorship W2039921189A5005882994 @default.
- W2039921189 hasAuthorship W2039921189A5013628889 @default.
- W2039921189 hasAuthorship W2039921189A5015263816 @default.
- W2039921189 hasAuthorship W2039921189A5020374246 @default.
- W2039921189 hasAuthorship W2039921189A5020490445 @default.
- W2039921189 hasAuthorship W2039921189A5023327838 @default.
- W2039921189 hasAuthorship W2039921189A5033816238 @default.
- W2039921189 hasAuthorship W2039921189A5070685116 @default.
- W2039921189 hasAuthorship W2039921189A5073554386 @default.
- W2039921189 hasAuthorship W2039921189A5077724687 @default.
- W2039921189 hasConcept C104317684 @default.
- W2039921189 hasConcept C109159458 @default.
- W2039921189 hasConcept C145103041 @default.
- W2039921189 hasConcept C203014093 @default.
- W2039921189 hasConcept C2777956040 @default.
- W2039921189 hasConcept C28328180 @default.
- W2039921189 hasConcept C54355233 @default.
- W2039921189 hasConcept C86803240 @default.
- W2039921189 hasConcept C95444343 @default.
- W2039921189 hasConceptScore W2039921189C104317684 @default.
- W2039921189 hasConceptScore W2039921189C109159458 @default.
- W2039921189 hasConceptScore W2039921189C145103041 @default.
- W2039921189 hasConceptScore W2039921189C203014093 @default.
- W2039921189 hasConceptScore W2039921189C2777956040 @default.
- W2039921189 hasConceptScore W2039921189C28328180 @default.
- W2039921189 hasConceptScore W2039921189C54355233 @default.
- W2039921189 hasConceptScore W2039921189C86803240 @default.
- W2039921189 hasConceptScore W2039921189C95444343 @default.
- W2039921189 hasIssue "5" @default.
- W2039921189 hasLocation W20399211891 @default.
- W2039921189 hasOpenAccess W2039921189 @default.
- W2039921189 hasPrimaryLocation W20399211891 @default.
- W2039921189 hasRelatedWork W1963923636 @default.
- W2039921189 hasRelatedWork W1996916774 @default.
- W2039921189 hasRelatedWork W2001072154 @default.
- W2039921189 hasRelatedWork W2074767953 @default.
- W2039921189 hasRelatedWork W2085168108 @default.
- W2039921189 hasRelatedWork W2119511363 @default.
- W2039921189 hasRelatedWork W2120223845 @default.
- W2039921189 hasRelatedWork W2125131568 @default.
- W2039921189 hasRelatedWork W2145374919 @default.
- W2039921189 hasRelatedWork W2552280904 @default.
- W2039921189 hasVolume "5" @default.
- W2039921189 isParatext "false" @default.
- W2039921189 isRetracted "false" @default.
- W2039921189 magId "2039921189" @default.
- W2039921189 workType "article" @default.