Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039927553> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2039927553 endingPage "46" @default.
- W2039927553 startingPage "31" @default.
- W2039927553 abstract "Caloric restriction (CR), known to extend median and maximum life spans, improve resistance to carcinogenesis, and significantly retard age-associated degenerative diseases in rodents, was previously reported to modulate levels of indigenous, age-dependent DNA modifications, called I-compounds, in male Brown-Norway (B-N) rats. Since profiles of these adduct-like derivatives are species-, strain-, sex-, and tissue-specific, we explored this apparent CR/I-compound relationship in a comparative study between male B-N and male Fischer 344 (F-344) rats, the latter having a shorter life expectancy and high incidence of renal disease. Control animals were fed NIH-31 diet ad libitum (AL), while the caloric intake of CR animals was limited to 60% of AL, starting at 3.5 months. Liver and kidney DNA from 1, 8, 12, 16, 24 (AL, CR), and 30 (CR only) month old rats was analyzed by 32P-postlabeling. Corresponding tissues from the two strains yielded similar DNA profiles. Total liver I-compound levels displayed 2.3-4.6-fold age-dependent increases from 1 to 24 months, and kidney values at 24 months were 5.2-8 times higher than those at 1 month. In both strains, I-compound levels of CR animals were higher, up to 2-fold, than in age-matched AL rats. Regression analyses indicated linear relationships between most CR relative adduct labeling values (both total and individual fractions) and age, whereas many AL values exhibited this type of link with log age. These findings confirm that a correlation exists between CR and I-compound levels, and, given the above physiological benefits of CR, indicate that I-compounds represent biomarkers of aging with potential utility in intervention studies." @default.
- W2039927553 created "2016-06-24" @default.
- W2039927553 creator A5033212305 @default.
- W2039927553 creator A5036324397 @default.
- W2039927553 creator A5056450528 @default.
- W2039927553 creator A5058280342 @default.
- W2039927553 creator A5067794700 @default.
- W2039927553 creator A5085291816 @default.
- W2039927553 date "1993-01-01" @default.
- W2039927553 modified "2023-10-14" @default.
- W2039927553 title "Enhancement of age-related increases in DNA I-compound levels by calorie restriction: comparison of male B-N and F-344 rats" @default.
- W2039927553 cites W1500548551 @default.
- W2039927553 cites W1972361162 @default.
- W2039927553 cites W1976178063 @default.
- W2039927553 cites W1982355620 @default.
- W2039927553 cites W1991893683 @default.
- W2039927553 cites W1993570794 @default.
- W2039927553 cites W2006834455 @default.
- W2039927553 cites W2019699086 @default.
- W2039927553 cites W2019781185 @default.
- W2039927553 cites W2023038194 @default.
- W2039927553 cites W2024816804 @default.
- W2039927553 cites W2030296332 @default.
- W2039927553 cites W2034094218 @default.
- W2039927553 cites W2046016170 @default.
- W2039927553 cites W2046338678 @default.
- W2039927553 cites W2047901478 @default.
- W2039927553 cites W2052774038 @default.
- W2039927553 cites W2059190195 @default.
- W2039927553 cites W2086526581 @default.
- W2039927553 cites W2087566245 @default.
- W2039927553 cites W2090853103 @default.
- W2039927553 cites W2128442121 @default.
- W2039927553 cites W2136723048 @default.
- W2039927553 cites W2141122084 @default.
- W2039927553 cites W2167143733 @default.
- W2039927553 cites W2327476431 @default.
- W2039927553 cites W2330329568 @default.
- W2039927553 doi "https://doi.org/10.1016/0921-8734(93)90009-r" @default.
- W2039927553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7677927" @default.
- W2039927553 hasPublicationYear "1993" @default.
- W2039927553 type Work @default.
- W2039927553 sameAs 2039927553 @default.
- W2039927553 citedByCount "23" @default.
- W2039927553 crossrefType "journal-article" @default.
- W2039927553 hasAuthorship W2039927553A5033212305 @default.
- W2039927553 hasAuthorship W2039927553A5036324397 @default.
- W2039927553 hasAuthorship W2039927553A5056450528 @default.
- W2039927553 hasAuthorship W2039927553A5058280342 @default.
- W2039927553 hasAuthorship W2039927553A5067794700 @default.
- W2039927553 hasAuthorship W2039927553A5085291816 @default.
- W2039927553 hasConcept C126322002 @default.
- W2039927553 hasConcept C134018914 @default.
- W2039927553 hasConcept C2778707264 @default.
- W2039927553 hasConcept C2780091579 @default.
- W2039927553 hasConcept C71924100 @default.
- W2039927553 hasConcept C86803240 @default.
- W2039927553 hasConceptScore W2039927553C126322002 @default.
- W2039927553 hasConceptScore W2039927553C134018914 @default.
- W2039927553 hasConceptScore W2039927553C2778707264 @default.
- W2039927553 hasConceptScore W2039927553C2780091579 @default.
- W2039927553 hasConceptScore W2039927553C71924100 @default.
- W2039927553 hasConceptScore W2039927553C86803240 @default.
- W2039927553 hasIssue "1" @default.
- W2039927553 hasLocation W20399275531 @default.
- W2039927553 hasLocation W20399275532 @default.
- W2039927553 hasOpenAccess W2039927553 @default.
- W2039927553 hasPrimaryLocation W20399275531 @default.
- W2039927553 hasRelatedWork W1966504330 @default.
- W2039927553 hasRelatedWork W1966775726 @default.
- W2039927553 hasRelatedWork W1979139803 @default.
- W2039927553 hasRelatedWork W1991560548 @default.
- W2039927553 hasRelatedWork W2030889776 @default.
- W2039927553 hasRelatedWork W2037631372 @default.
- W2039927553 hasRelatedWork W2040058909 @default.
- W2039927553 hasRelatedWork W2063957970 @default.
- W2039927553 hasRelatedWork W2132898409 @default.
- W2039927553 hasRelatedWork W4249176446 @default.
- W2039927553 hasVolume "295" @default.
- W2039927553 isParatext "false" @default.
- W2039927553 isRetracted "false" @default.
- W2039927553 magId "2039927553" @default.
- W2039927553 workType "article" @default.