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- W2039930914 abstract "The microstructural characterization of metacryloyloxyethyl [2-(acetyloxy)-4-(trifluoromethyl)]benzoate (THEMA) and 2-acrylamido-2-metylpropanesulfonic acid (AMPS) copolymers (THA) is described. Both monomers presented a high differential reactivity in copolymerization (the reactivity ratios have been determined, rTHEMA = 4.54 and rAMPS = 0.32), and the monomer incorporation to the copolymer chains is quite heterogeneous: the more reactive THEMA is incorporated preferentially in the first steps of the reaction and AMPS in last stages. Two rich THEMA copolymers (0.60 and 0.80 THEMA feed molar fraction), as well as the homopolymer, have been used for in vitro Triflusal (Disgren) release experiments, giving rise to zero-order profiles. A kinetic model called the “progressive accessibility model” has been developed in order to explain the zero-order kinetics of Triflusal release from AMPS−THEMA copolymers in different media, at pH = 2.0, 7.4, and 10.0. The experimental results fit adequately the model, which considers the accessibility of the hydrolyzable THEMA units controlled by the microstructural distribution of these units in copolymer sequences." @default.
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- W2039930914 date "2003-10-22" @default.
- W2039930914 modified "2023-09-27" @default.
- W2039930914 title "A Kinetic Model To Explain the Zero-Order Release of Drugs from Ionic Polymeric Drug Conjugates: Application to AMPS−Triflusal-Derived Polymeric Drugs" @default.
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- W2039930914 doi "https://doi.org/10.1021/ma034248v" @default.
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