Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039931321> ?p ?o ?g. }
- W2039931321 endingPage "735" @default.
- W2039931321 startingPage "729" @default.
- W2039931321 abstract "Aims: To evaluate whether carvedilol influences exercise hyperventilation and the ventilatory response to hypoxia in heart failure (HF). Methods and results: Fifteen HF patients participated to this double blind, randomised, placebo controlled, cross-over study. Patients were evaluated by quality of life questionnaire, echocardiography, pulmonary function and cardiopulmonary exercise tests (ramp and constant workload) both in normoxia (FiO2=21%) and hypoxia (FiO2=16%, equivalent to a simulated altitude of 2000m). Carvedilol improved clinical condition and reduced left ventricle size, but had no effect on lung mechanics. In normoxia during exercise, ventilation was lower, VCO2 unchanged and PaCO2 (constant workload) or PetCO2 (ramp) higher with carvedilol, exercise capacity was unchanged (peak workload 92±22 and 90±22W for placebo and carvedilol, respectively). Abnormal VE/VCO2 slope was reduced by carvedilol. Hypoxia increased ventilation but less with carvedilol; exercise capacity decreased to 87±21W (placebo) and to 80±11W (carvedilol, p<0.01). With hypoxia, carvedilol decreased VE/VCO2 slope. At constant workload exercise with hypoxia, PaO2 decreased to 69±6 mm Hg (placebo) and to 64±5 (carvedilol, p<0.01). Conclusion: Carvedilol reduced hyperventilation possibly by reducing peripheral chemoreflex sensitivity as suggested by PaCO2 increase with normoxia and PaO2 decrease with hypoxia without VCO2 and VD/VT changes. Lessening hyperventilation is beneficial when breathing normally, but detrimental when hyperventilation is needed for exercise at high altitude." @default.
- W2039931321 created "2016-06-24" @default.
- W2039931321 creator A5000029547 @default.
- W2039931321 creator A5029860974 @default.
- W2039931321 creator A5041820050 @default.
- W2039931321 creator A5050956445 @default.
- W2039931321 creator A5054603662 @default.
- W2039931321 creator A5055881757 @default.
- W2039931321 creator A5070050432 @default.
- W2039931321 creator A5074531142 @default.
- W2039931321 creator A5082276539 @default.
- W2039931321 date "2006-10-28" @default.
- W2039931321 modified "2023-10-17" @default.
- W2039931321 title "Carvedilol reduces exercise-induced hyperventilation: A benefit in normoxia and a problem with hypoxia" @default.
- W2039931321 cites W1543949054 @default.
- W2039931321 cites W1964059713 @default.
- W2039931321 cites W1965544649 @default.
- W2039931321 cites W1973798888 @default.
- W2039931321 cites W1974907870 @default.
- W2039931321 cites W1980833708 @default.
- W2039931321 cites W1986817239 @default.
- W2039931321 cites W1989001704 @default.
- W2039931321 cites W2002606850 @default.
- W2039931321 cites W2005097795 @default.
- W2039931321 cites W2007213042 @default.
- W2039931321 cites W2016532277 @default.
- W2039931321 cites W2016709367 @default.
- W2039931321 cites W2020358342 @default.
- W2039931321 cites W2045710135 @default.
- W2039931321 cites W2054105133 @default.
- W2039931321 cites W2056665255 @default.
- W2039931321 cites W2072307720 @default.
- W2039931321 cites W2072834559 @default.
- W2039931321 cites W2080396207 @default.
- W2039931321 cites W2082351345 @default.
- W2039931321 cites W2099733156 @default.
- W2039931321 cites W2117230676 @default.
- W2039931321 cites W2117545706 @default.
- W2039931321 cites W2121166015 @default.
- W2039931321 cites W2124763644 @default.
- W2039931321 cites W2138613339 @default.
- W2039931321 cites W2145139856 @default.
- W2039931321 cites W2160005411 @default.
- W2039931321 cites W2169722543 @default.
- W2039931321 cites W2171369609 @default.
- W2039931321 cites W2172025889 @default.
- W2039931321 cites W2180610019 @default.
- W2039931321 cites W2271010007 @default.
- W2039931321 cites W2326508838 @default.
- W2039931321 cites W4249200669 @default.
- W2039931321 doi "https://doi.org/10.1016/j.ejheart.2006.02.001" @default.
- W2039931321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16533619" @default.
- W2039931321 hasPublicationYear "2006" @default.
- W2039931321 type Work @default.
- W2039931321 sameAs 2039931321 @default.
- W2039931321 citedByCount "52" @default.
- W2039931321 countsByYear W20399313212012 @default.
- W2039931321 countsByYear W20399313212013 @default.
- W2039931321 countsByYear W20399313212014 @default.
- W2039931321 countsByYear W20399313212016 @default.
- W2039931321 countsByYear W20399313212017 @default.
- W2039931321 countsByYear W20399313212018 @default.
- W2039931321 countsByYear W20399313212020 @default.
- W2039931321 countsByYear W20399313212021 @default.
- W2039931321 countsByYear W20399313212022 @default.
- W2039931321 countsByYear W20399313212023 @default.
- W2039931321 crossrefType "journal-article" @default.
- W2039931321 hasAuthorship W2039931321A5000029547 @default.
- W2039931321 hasAuthorship W2039931321A5029860974 @default.
- W2039931321 hasAuthorship W2039931321A5041820050 @default.
- W2039931321 hasAuthorship W2039931321A5050956445 @default.
- W2039931321 hasAuthorship W2039931321A5054603662 @default.
- W2039931321 hasAuthorship W2039931321A5055881757 @default.
- W2039931321 hasAuthorship W2039931321A5070050432 @default.
- W2039931321 hasAuthorship W2039931321A5074531142 @default.
- W2039931321 hasAuthorship W2039931321A5082276539 @default.
- W2039931321 hasBestOaLocation W20399313211 @default.
- W2039931321 hasConcept C126322002 @default.
- W2039931321 hasConcept C142724271 @default.
- W2039931321 hasConcept C164705383 @default.
- W2039931321 hasConcept C178790620 @default.
- W2039931321 hasConcept C185592680 @default.
- W2039931321 hasConcept C204787440 @default.
- W2039931321 hasConcept C27081682 @default.
- W2039931321 hasConcept C2777449187 @default.
- W2039931321 hasConcept C2778198053 @default.
- W2039931321 hasConcept C2780591200 @default.
- W2039931321 hasConcept C42219234 @default.
- W2039931321 hasConcept C534529494 @default.
- W2039931321 hasConcept C540031477 @default.
- W2039931321 hasConcept C71924100 @default.
- W2039931321 hasConcept C7836513 @default.
- W2039931321 hasConcept C79959777 @default.
- W2039931321 hasConceptScore W2039931321C126322002 @default.
- W2039931321 hasConceptScore W2039931321C142724271 @default.
- W2039931321 hasConceptScore W2039931321C164705383 @default.
- W2039931321 hasConceptScore W2039931321C178790620 @default.
- W2039931321 hasConceptScore W2039931321C185592680 @default.