Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039934617> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2039934617 endingPage "426" @default.
- W2039934617 startingPage "417" @default.
- W2039934617 abstract "Integrated systems combining functional (single-photon emission computed tomography; SPECT) imaging with anatomic (computed tomography; CT) imaging have the potential to greatly improve the accuracy of dose estimation in radionuclide therapy. In this article, we present the methodology for highly patient-specific tumor dosimetry by utilizing such a system and apply it to a pilot study of 4 follicular lymphoma patients treated with I-131 tositumomab. SPECT quantification included three-dimensional ordered-subset expectation-maximization reconstruction and CT-defined tumor outlines at each time point. SPECT/CT images from multiple time points were coupled to a Monte Carlo algorithm to calculate a mean tumor dose that incorporated measured changes in tumor volume. The tumor shrinkage, defined as the difference between volumes drawn on the first and last CT scan (a typical time period of 15 days) was in the range 5%-49%. The therapy-delivered mean tumor-absorbed dose was in the range 146-334 cGy. For comparison, the therapy dose was also calculated by assuming a static volume from the initial CT and was found to underestimate this dose by up to 47%. The agreement between tracer-predicted and therapy-delivered tumor-absorbed dose was in the range 7%-21%. In summary, malignant lymphomas can have dramatic tumor regression within days of treatment, and advanced imaging methods allow for a highly patient-specific tumor-dosimetry calculation that accounts for this regression." @default.
- W2039934617 created "2016-06-24" @default.
- W2039934617 creator A5002622134 @default.
- W2039934617 creator A5034458018 @default.
- W2039934617 creator A5044202420 @default.
- W2039934617 creator A5065982764 @default.
- W2039934617 creator A5080366682 @default.
- W2039934617 date "2009-08-01" @default.
- W2039934617 modified "2023-09-27" @default.
- W2039934617 title "Use of Integrated SPECT/CT Imaging for Tumor Dosimetry in I-131 Radioimmunotherapy: A Pilot Patient Study" @default.
- W2039934617 cites W1869307723 @default.
- W2039934617 cites W1892026381 @default.
- W2039934617 cites W1996677204 @default.
- W2039934617 cites W2007835787 @default.
- W2039934617 cites W2013770655 @default.
- W2039934617 cites W2014654561 @default.
- W2039934617 cites W2022936245 @default.
- W2039934617 cites W2023676835 @default.
- W2039934617 cites W2046446448 @default.
- W2039934617 cites W2053391510 @default.
- W2039934617 cites W2099216222 @default.
- W2039934617 cites W2107233513 @default.
- W2039934617 cites W2126539571 @default.
- W2039934617 cites W2128968395 @default.
- W2039934617 cites W2145028545 @default.
- W2039934617 cites W2179595152 @default.
- W2039934617 doi "https://doi.org/10.1089/cbr.2008.0568" @default.
- W2039934617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2841975" @default.
- W2039934617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19694576" @default.
- W2039934617 hasPublicationYear "2009" @default.
- W2039934617 type Work @default.
- W2039934617 sameAs 2039934617 @default.
- W2039934617 citedByCount "32" @default.
- W2039934617 countsByYear W20399346172012 @default.
- W2039934617 countsByYear W20399346172013 @default.
- W2039934617 countsByYear W20399346172014 @default.
- W2039934617 countsByYear W20399346172015 @default.
- W2039934617 countsByYear W20399346172016 @default.
- W2039934617 countsByYear W20399346172019 @default.
- W2039934617 countsByYear W20399346172020 @default.
- W2039934617 countsByYear W20399346172021 @default.
- W2039934617 countsByYear W20399346172022 @default.
- W2039934617 crossrefType "journal-article" @default.
- W2039934617 hasAuthorship W2039934617A5002622134 @default.
- W2039934617 hasAuthorship W2039934617A5034458018 @default.
- W2039934617 hasAuthorship W2039934617A5044202420 @default.
- W2039934617 hasAuthorship W2039934617A5065982764 @default.
- W2039934617 hasAuthorship W2039934617A5080366682 @default.
- W2039934617 hasBestOaLocation W20399346172 @default.
- W2039934617 hasConcept C126838900 @default.
- W2039934617 hasConcept C151337348 @default.
- W2039934617 hasConcept C159654299 @default.
- W2039934617 hasConcept C203014093 @default.
- W2039934617 hasConcept C2776146153 @default.
- W2039934617 hasConcept C2984398910 @default.
- W2039934617 hasConcept C2989005 @default.
- W2039934617 hasConcept C2993559085 @default.
- W2039934617 hasConcept C31601959 @default.
- W2039934617 hasConcept C509974204 @default.
- W2039934617 hasConcept C542903549 @default.
- W2039934617 hasConcept C71924100 @default.
- W2039934617 hasConcept C75088862 @default.
- W2039934617 hasConceptScore W2039934617C126838900 @default.
- W2039934617 hasConceptScore W2039934617C151337348 @default.
- W2039934617 hasConceptScore W2039934617C159654299 @default.
- W2039934617 hasConceptScore W2039934617C203014093 @default.
- W2039934617 hasConceptScore W2039934617C2776146153 @default.
- W2039934617 hasConceptScore W2039934617C2984398910 @default.
- W2039934617 hasConceptScore W2039934617C2989005 @default.
- W2039934617 hasConceptScore W2039934617C2993559085 @default.
- W2039934617 hasConceptScore W2039934617C31601959 @default.
- W2039934617 hasConceptScore W2039934617C509974204 @default.
- W2039934617 hasConceptScore W2039934617C542903549 @default.
- W2039934617 hasConceptScore W2039934617C71924100 @default.
- W2039934617 hasConceptScore W2039934617C75088862 @default.
- W2039934617 hasIssue "4" @default.
- W2039934617 hasLocation W20399346171 @default.
- W2039934617 hasLocation W20399346172 @default.
- W2039934617 hasLocation W20399346173 @default.
- W2039934617 hasLocation W20399346174 @default.
- W2039934617 hasLocation W20399346175 @default.
- W2039934617 hasOpenAccess W2039934617 @default.
- W2039934617 hasPrimaryLocation W20399346171 @default.
- W2039934617 hasRelatedWork W1964713829 @default.
- W2039934617 hasRelatedWork W1981223719 @default.
- W2039934617 hasRelatedWork W2017884723 @default.
- W2039934617 hasRelatedWork W2039934617 @default.
- W2039934617 hasRelatedWork W2160751658 @default.
- W2039934617 hasRelatedWork W2545086415 @default.
- W2039934617 hasRelatedWork W2768013131 @default.
- W2039934617 hasRelatedWork W2891903857 @default.
- W2039934617 hasRelatedWork W2971112970 @default.
- W2039934617 hasRelatedWork W3161464386 @default.
- W2039934617 hasVolume "24" @default.
- W2039934617 isParatext "false" @default.
- W2039934617 isRetracted "false" @default.
- W2039934617 magId "2039934617" @default.
- W2039934617 workType "article" @default.