Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039948844> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2039948844 endingPage "359" @default.
- W2039948844 startingPage "357" @default.
- W2039948844 abstract "In recent years we have seen a breakthrough in the use of biologics for the treatment of chronic inf lammatory diseases. For over 10 years, patients with rheumatoid arthritis have been treated with inhibitors of the cyto‐ kine TNF‐α, such as monoclonal antibodies or a soluble TNF‐α receptor protein [1]. More recently, blockade of the IL‐6 pathway using a monoclonal antibody against the human IL‐6 receptor (IL‐6R) has been approved in Japan, Europe and the USA [2]. Many more IL‐6‐ targeting antibodies are in clinical trials or in preclinical development, underlining the grow‐ ing interest in blockade of the cytokine IL‐6 [3]. Although the therapeutic success of the TNF‐α and IL‐6 pathway blockades is impressive, it should be kept in mind that not all patients respond to therapy with a given biologic and that cytokine blockade may lead to an impair‐ ment of the immune system [1–3]. Therefore, novel approaches and therapeutic strategies are urgently warranted. It has been recognized that the signal‐ ing pathways of TNF‐α and IL‐6 are both regulated by the membrane‐bound metallo‐ proteinase ADAM17. TNF‐α is a type II trans‐ membrane protein, which only becomes sys‐ temically available after cleavage by ADAM17 [4,5]. Conditional gene targeting of ADAM17 in murine myeloid cells resulted in a loss of shed‐ ding of TNF‐α from the cell surface and, more‐ over, resistance to lipopolysaccharide‐mediated septic shock [6]. This indicated that the pro‐ inf lammatory activity of TNF‐α requires cleavage by ADAM17. This interpretation was strongly supported by the finding that mice expressing an uncleavable version of TNF‐α are protected against intracellular bacterial infec‐ tions, chronic inflammation and autoimmunity [7]. It appears, therefore, that the membrane ver‐ sion of TNF‐α acts via an anti‐inflammatory" @default.
- W2039948844 created "2016-06-24" @default.
- W2039948844 creator A5006634561 @default.
- W2039948844 creator A5057570590 @default.
- W2039948844 date "2012-08-01" @default.
- W2039948844 modified "2023-10-18" @default.
- W2039948844 title "ADAM17: a potential therapeutic target for rheumatoid arthritis?" @default.
- W2039948844 cites W1970535801 @default.
- W2039948844 cites W1971308765 @default.
- W2039948844 cites W1975789669 @default.
- W2039948844 cites W2012967865 @default.
- W2039948844 cites W2022650366 @default.
- W2039948844 cites W2036842448 @default.
- W2039948844 cites W2036988498 @default.
- W2039948844 cites W2057671535 @default.
- W2039948844 cites W2062926560 @default.
- W2039948844 cites W2074881372 @default.
- W2039948844 cites W2106527818 @default.
- W2039948844 cites W2110463517 @default.
- W2039948844 cites W2114853101 @default.
- W2039948844 cites W2125396722 @default.
- W2039948844 cites W2130487791 @default.
- W2039948844 cites W2134714663 @default.
- W2039948844 cites W2139819066 @default.
- W2039948844 cites W2141267620 @default.
- W2039948844 cites W2141436693 @default.
- W2039948844 cites W2413878094 @default.
- W2039948844 doi "https://doi.org/10.2217/ijr.12.42" @default.
- W2039948844 hasPublicationYear "2012" @default.
- W2039948844 type Work @default.
- W2039948844 sameAs 2039948844 @default.
- W2039948844 citedByCount "3" @default.
- W2039948844 countsByYear W20399488442017 @default.
- W2039948844 countsByYear W20399488442021 @default.
- W2039948844 countsByYear W20399488442022 @default.
- W2039948844 crossrefType "journal-article" @default.
- W2039948844 hasAuthorship W2039948844A5006634561 @default.
- W2039948844 hasAuthorship W2039948844A5057570590 @default.
- W2039948844 hasConcept C126322002 @default.
- W2039948844 hasConcept C159654299 @default.
- W2039948844 hasConcept C170493617 @default.
- W2039948844 hasConcept C17991360 @default.
- W2039948844 hasConcept C203014093 @default.
- W2039948844 hasConcept C2777575956 @default.
- W2039948844 hasConcept C2778468042 @default.
- W2039948844 hasConcept C2778690821 @default.
- W2039948844 hasConcept C502942594 @default.
- W2039948844 hasConcept C542903549 @default.
- W2039948844 hasConcept C71924100 @default.
- W2039948844 hasConceptScore W2039948844C126322002 @default.
- W2039948844 hasConceptScore W2039948844C159654299 @default.
- W2039948844 hasConceptScore W2039948844C170493617 @default.
- W2039948844 hasConceptScore W2039948844C17991360 @default.
- W2039948844 hasConceptScore W2039948844C203014093 @default.
- W2039948844 hasConceptScore W2039948844C2777575956 @default.
- W2039948844 hasConceptScore W2039948844C2778468042 @default.
- W2039948844 hasConceptScore W2039948844C2778690821 @default.
- W2039948844 hasConceptScore W2039948844C502942594 @default.
- W2039948844 hasConceptScore W2039948844C542903549 @default.
- W2039948844 hasConceptScore W2039948844C71924100 @default.
- W2039948844 hasIssue "4" @default.
- W2039948844 hasLocation W20399488441 @default.
- W2039948844 hasOpenAccess W2039948844 @default.
- W2039948844 hasPrimaryLocation W20399488441 @default.
- W2039948844 hasRelatedWork W143814642 @default.
- W2039948844 hasRelatedWork W168973904 @default.
- W2039948844 hasRelatedWork W1692255419 @default.
- W2039948844 hasRelatedWork W1737140009 @default.
- W2039948844 hasRelatedWork W1967436988 @default.
- W2039948844 hasRelatedWork W1994529307 @default.
- W2039948844 hasRelatedWork W2033120898 @default.
- W2039948844 hasRelatedWork W2102672728 @default.
- W2039948844 hasRelatedWork W2166494141 @default.
- W2039948844 hasRelatedWork W22473413 @default.
- W2039948844 hasRelatedWork W2286779522 @default.
- W2039948844 hasRelatedWork W2403800171 @default.
- W2039948844 hasRelatedWork W2416693367 @default.
- W2039948844 hasRelatedWork W2473589432 @default.
- W2039948844 hasRelatedWork W2522977978 @default.
- W2039948844 hasRelatedWork W2527755690 @default.
- W2039948844 hasRelatedWork W2897868566 @default.
- W2039948844 hasRelatedWork W3182038357 @default.
- W2039948844 hasRelatedWork W63864630 @default.
- W2039948844 hasRelatedWork W75606589 @default.
- W2039948844 hasVolume "7" @default.
- W2039948844 isParatext "false" @default.
- W2039948844 isRetracted "false" @default.
- W2039948844 magId "2039948844" @default.
- W2039948844 workType "article" @default.