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- W2039948897 abstract "The vast majority of meiotic recombination events (crossovers (COs) and non-crossovers (NCOs)) cluster in narrow hotspots surrounded by large regions devoid of recombinational activity. Here, using a new molecular approach in plants, called “pollen-typing”, we detected and characterized hundreds of CO and NCO molecules in two different hotspot regions in Arabidopsis thaliana. This analysis revealed that COs are concentrated in regions of a few kilobases where their rates reach up to 50 times the genome average. The hotspots themselves tend to cluster in regions less than 8 kilobases in size with overlapping CO distribution. Non-crossover (NCO) events also occurred in the two hotspots but at very different levels (local CO/NCO ratios of 1/1 and 30/1) and their track lengths were quite small (a few hundred base pairs). We also showed that the ZMM protein MSH4 plays a role in CO formation and somewhat unexpectedly we also found that it is involved in the generation of NCOs but with a different level of effect. Finally, factors acting in cis and in trans appear to shape the rate and distribution of COs at meiotic recombination hotspots." @default.
- W2039948897 created "2016-06-24" @default.
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- W2039948897 date "2013-11-14" @default.
- W2039948897 modified "2023-09-30" @default.
- W2039948897 title "Contrasted Patterns of Crossover and Non-crossover at Arabidopsis thaliana Meiotic Recombination Hotspots" @default.
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- W2039948897 doi "https://doi.org/10.1371/journal.pgen.1003922" @default.
- W2039948897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3828143" @default.
- W2039948897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24244190" @default.
- W2039948897 hasPublicationYear "2013" @default.
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