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• W2039949241 abstract "Although anecdotal and correlational results have suggested a reliable relationship between creativity and psychosis, few studies have examined this relationship using empirical methods. In addition, little is known about the neural substrates of creative thinking. We investigated the creative thinking process in relation to schizotypal personality, schizophrenia and prefrontal hemispheric laterality using behavioral and near-infrared optical spectroscopy (NIRS) methods. Schizophrenic, psychometrically ascertained schizotypal, and healthy control subjects (all right-handed) participated in a novel alternate uses task designed to assess divergent thinking (DT) ability. The DT task required subjects to generate uses for conventional and ambiguous objects. Prefrontal activity was measured using NIRS while subjects were engaged in DT vs. a cognitive control task in a subset of the subjects. Behavioral data indicated that schizotypes had enhanced DT ability compared with schizophrenic and control subjects, who showed similar performance overall. NIRS data showed that DT was associated with bilateral prefrontal cortex (PFC) activation, but the right PFC particularly contributed to the enhanced creative thinking in psychometric schizotypes compared with the other two groups. Thus, creative thinking seems to robustly recruit bilateral PFC, but it is the right PFC that is preferentially activated in schizotypes in relation to their enhanced DT." @default.
• W2039949241 created "2016-06-24" @default.
• W2039949241 creator A5019834339 @default.
• W2039949241 creator A5076490346 @default.
• W2039949241 date "2005-12-01" @default.
• W2039949241 modified "2023-10-13" @default.
• W2039949241 title "Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: A behavioral and near-infrared optical imaging study" @default.
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• W2039949241 doi "https://doi.org/10.1016/j.schres.2005.06.016" @default.
• W2039949241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817946" @default.
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