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- W2039950005 abstract "Abstract: The endothelium modulates vascular tone by producing vasodilator andvasoconstrictor substances. Of these, the best characterized and potentially most important are nitric oxide (NO•) and O2−•. These small molecules exhibit opposing effects on vascular tone and chemically react with each other in a fashion that negates their individual effects and leads to the production of potentially toxic substances, such as peroxynitrite (ONOO−). These dynamic interactions may likely have important implications, altering not only tissue perfusion but also contributing to the process of atherosclerosis. The precise O2−• source within vascular tissue remains to be determined. Recent work demonstrated that in endothelial cells as well as in vascular smooth muscle cells, a membrane-associated NAD(P)H-dependent oxidase represents the most significant O2−• source. Interestingly, this oxidase is activated upon stimulation with angiotensin II, suggesting that under all conditions of an activated circulating and/or local renin-angiotensin system endothelial dysfunction secondary to increased vascular O2−• production is expected." @default.
- W2039950005 created "2016-06-24" @default.
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- W2039950005 date "1999-06-01" @default.
- W2039950005 modified "2023-09-23" @default.
- W2039950005 title "Role for NADPH/NADH Oxidase in the Modulation of Vascular Tonea" @default.
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- W2039950005 doi "https://doi.org/10.1111/j.1749-6632.1999.tb09253.x" @default.
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