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- W2039968220 abstract "Hematopoietic stem cells (HSCs) emerge during embryogenesis from hemogenic endothelium, but it remains unclear how the HSC lineage is initially established from mesoderm during ontogeny. In Xenopus, the definitive hemangioblast precursors of the HSC lineage have been identified in dorsal lateral plate (DLP) mesoderm, and a transcriptional gene regulatory network (GRN) controlling hemangioblast programming has been elucidated. Herein, we identify an essential role for microRNAs (miRNAs) in establishing the mesodermal lineage leading to both HSC emergence and vasculogenesis and determine that a single miRNA, miR-142-3p, is primarily responsible for initiation of definitive hemangioblast specification. miR-142-3p forms a double-negative gate unlocking entry into the hemangioblast program, in part by inhibiting TGFβ signaling. Our results table miR-142-3p as a master regulator of HSC lineage specification, sitting at the apex of the hierarchy programming the adult hemangioblast, thus illustrating that miRNAs can act as instructive determinants of cell fate during development." @default.
- W2039968220 created "2016-06-24" @default.
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- W2039968220 date "2013-08-01" @default.
- W2039968220 modified "2023-10-12" @default.
- W2039968220 title "miR-142-3p Controls the Specification of Definitive Hemangioblasts during Ontogeny" @default.
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- W2039968220 cites W1974595624 @default.
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- W2039968220 cites W1993652391 @default.
- W2039968220 cites W1998200666 @default.
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- W2039968220 cites W2018973621 @default.
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- W2039968220 doi "https://doi.org/10.1016/j.devcel.2013.06.023" @default.
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