FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039968377> ?p ?o ?g. }

• W2039968377 endingPage "2825" @default.
• W2039968377 startingPage "2819" @default.
• W2039968377 abstract "Chromatoid bodies are thought to act as male-germ-cell-specific platforms for the storing and processing of haploid transcripts. The molecular mechanisms governing the formation and function of these germ-cell-specific structures have remained elusive. In this study, we show that the kinesin motor protein KIF17b, which is involved in the nucleocytoplasmic transport of RNA and of a transcriptional coactivator, localizes in chromatoid bodies. The chromatoid body moves actively and non-randomly in the cytoplasm of round spermatids, making frequent contacts with the nuclear envelope. The localization of KIF17b thereby offers a potential mechanism for microtubule-dependent mobility of chromatoid bodies, as well as for the transport of the specific components in and out of the chromatoid body. Interestingly, we demonstrate that KIF17b physically interacts with a testis-specific member of the PIWI/Argonaute family, MIWI, a component of chromatoid bodies implicated in RNA metabolism. A functional interplay between KIF17b and MIWI might be needed for the loading of haploid RNAs in the chromatoid body. Importantly, chromatoid bodies from round spermatids of miwi-null mice are not fully compacted and remain as a diffuse chromatoid material, revealing the essential role played by MIWI in the formation of chromatoid bodies. These results shed new light on the function of chromatoid bodies in the post-transcriptional regulation of gene expression in haploid germ cells." @default.
• W2039968377 created "2016-06-24" @default.
• W2039968377 creator A5007131600 @default.
• W2039968377 creator A5015673000 @default.
• W2039968377 creator A5034335838 @default.
• W2039968377 creator A5064331844 @default.
• W2039968377 date "2006-07-01" @default.
• W2039968377 modified "2023-10-16" @default.
• W2039968377 title "Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells" @default.
• W2039968377 cites W1499999049 @default.
• W2039968377 cites W1512350132 @default.
• W2039968377 cites W1912418335 @default.
• W2039968377 cites W1965049397 @default.
• W2039968377 cites W1976435237 @default.
• W2039968377 cites W1986299882 @default.
• W2039968377 cites W1998307780 @default.
• W2039968377 cites W2003459332 @default.
• W2039968377 cites W2005673370 @default.
• W2039968377 cites W2009368365 @default.
• W2039968377 cites W2015015700 @default.
• W2039968377 cites W2025635760 @default.
• W2039968377 cites W2029562995 @default.
• W2039968377 cites W2030411939 @default.
• W2039968377 cites W2041306541 @default.
• W2039968377 cites W2043374535 @default.
• W2039968377 cites W2045461552 @default.
• W2039968377 cites W2045677887 @default.
• W2039968377 cites W2047649140 @default.
• W2039968377 cites W2051410315 @default.
• W2039968377 cites W2055742810 @default.
• W2039968377 cites W2058176738 @default.
• W2039968377 cites W2063149633 @default.
• W2039968377 cites W2069657104 @default.
• W2039968377 cites W2072153827 @default.
• W2039968377 cites W2076983324 @default.
• W2039968377 cites W2084980375 @default.
• W2039968377 cites W2092450381 @default.
• W2039968377 cites W2099874946 @default.
• W2039968377 cites W2101543035 @default.
• W2039968377 cites W2107887850 @default.
• W2039968377 cites W2113083989 @default.
• W2039968377 cites W2116077211 @default.
• W2039968377 cites W2128958626 @default.
• W2039968377 cites W2129895314 @default.
• W2039968377 cites W2133058137 @default.
• W2039968377 cites W2135837360 @default.
• W2039968377 cites W2168436056 @default.
• W2039968377 cites W2337510939 @default.
• W2039968377 doi "https://doi.org/10.1242/jcs.03022" @default.
• W2039968377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16787948" @default.
• W2039968377 hasPublicationYear "2006" @default.
• W2039968377 type Work @default.
• W2039968377 sameAs 2039968377 @default.
• W2039968377 citedByCount "125" @default.
• W2039968377 countsByYear W20399683772012 @default.
• W2039968377 countsByYear W20399683772013 @default.
• W2039968377 countsByYear W20399683772014 @default.
• W2039968377 countsByYear W20399683772015 @default.
• W2039968377 countsByYear W20399683772016 @default.
• W2039968377 countsByYear W20399683772017 @default.
• W2039968377 countsByYear W20399683772018 @default.
• W2039968377 countsByYear W20399683772019 @default.
• W2039968377 countsByYear W20399683772020 @default.
• W2039968377 countsByYear W20399683772021 @default.
• W2039968377 countsByYear W20399683772022 @default.
• W2039968377 countsByYear W20399683772023 @default.
• W2039968377 crossrefType "journal-article" @default.
• W2039968377 hasAuthorship W2039968377A5007131600 @default.
• W2039968377 hasAuthorship W2039968377A5015673000 @default.
• W2039968377 hasAuthorship W2039968377A5034335838 @default.
• W2039968377 hasAuthorship W2039968377A5064331844 @default.
• W2039968377 hasBestOaLocation W20399683771 @default.
• W2039968377 hasConcept C104317684 @default.
• W2039968377 hasConcept C147724379 @default.
• W2039968377 hasConcept C166703698 @default.
• W2039968377 hasConcept C201853390 @default.
• W2039968377 hasConcept C2779122487 @default.
• W2039968377 hasConcept C54355233 @default.
• W2039968377 hasConcept C67705224 @default.
• W2039968377 hasConcept C86803240 @default.
• W2039968377 hasConcept C95444343 @default.
• W2039968377 hasConceptScore W2039968377C104317684 @default.
• W2039968377 hasConceptScore W2039968377C147724379 @default.
• W2039968377 hasConceptScore W2039968377C166703698 @default.
• W2039968377 hasConceptScore W2039968377C201853390 @default.
• W2039968377 hasConceptScore W2039968377C2779122487 @default.
• W2039968377 hasConceptScore W2039968377C54355233 @default.
• W2039968377 hasConceptScore W2039968377C67705224 @default.
• W2039968377 hasConceptScore W2039968377C86803240 @default.
• W2039968377 hasConceptScore W2039968377C95444343 @default.
• W2039968377 hasIssue "13" @default.
• W2039968377 hasLocation W20399683771 @default.
• W2039968377 hasLocation W20399683772 @default.
• W2039968377 hasLocation W20399683773 @default.
• W2039968377 hasLocation W20399683774 @default.
• W2039968377 hasOpenAccess W2039968377 @default.
• W2039968377 hasPrimaryLocation W20399683771 @default.
• W2039968377 hasRelatedWork W1971388540 @default.

• next