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• W2039969351 abstract "The search for cellular correlates of learning is a major challenge in neurobiology. The hippocampal formation is important for learning spatial relations. A possible long-lasting consequence of such spatial learning is alteration of the size, shape, or number of excitatory synapses. The dendritic spine density is a good index for the number of hippocampal excitatory synapses. By using laser-scanning confocal microscopy, we observed a significantly increased spine density in CA1 basal dendrites of spatially trained rats when compared to nontrained controls. With unchanged dendritic length, the higher spine density reflects an increased number of excitatory synapses per neuron associated with spatial learning." @default.
• W2039969351 created "2016-06-24" @default.
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• W2039969351 date "1994-12-20" @default.
• W2039969351 modified "2023-10-14" @default.
• W2039969351 title "An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses." @default.
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• W2039969351 doi "https://doi.org/10.1073/pnas.91.26.12673" @default.
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