FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039980771> ?p ?o ?g. }

• W2039980771 endingPage "490" @default.
• W2039980771 startingPage "479" @default.
• W2039980771 abstract "1. Little is known about metabolism of xenobiotics by earthworms, despite their importance in soil ecotoxicity testing. Normal earthworms and earthworms treated with antibiotics to ensure inhibition of gut microflora were exposed to two model xenobiotic compounds, 4-fluoroaniline and 4-fluorobiphenyl, to determine which metabolites were produced, and whether the pattern of metabolism was affected by the presence of microbial transformation ability. 2. (19)F-NMR spectroscopy detected the number and relative proportions of metabolites and directly coupled HPLC-(1)H-NMR spectroscopy and HPLC-MS then identified the metabolites. 3. Despite uptake, no metabolism of 4-fluorobiphenyl was observed at any stage, which appears to be a consequence of the lack of oxidative Phase I metabolic activity of the earthworms towards this substrate. In contrast, 4-fluoroaniline exhibited dose-dependent metabolism. At high doses (leading to mortality within 24 h) one predominant metabolite was observed, which was identified as the N-beta-glucoside conjugate. At lower dose levels, the predominant metabolite was the gamma-glutamyl conjugate, although the glucoside and another as yet unidentified metabolite were also detected. 4. The inhibition of gut microflora did not have any influence on metabolism. The study represents the first evidence for glucoside and glutamyl conjugation as a pathway for xenobiotic metabolism in earthworms." @default.
• W2039980771 created "2016-06-24" @default.
• W2039980771 creator A5017217956 @default.
• W2039980771 creator A5018207002 @default.
• W2039980771 creator A5028056295 @default.
• W2039980771 creator A5031520863 @default.
• W2039980771 creator A5060535056 @default.
• W2039980771 creator A5064846441 @default.
• W2039980771 date "2002-01-01" @default.
• W2039980771 modified "2023-09-30" @default.
• W2039980771 title "Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS" @default.
• W2039980771 cites W1968479752 @default.
• W2039980771 cites W1995883919 @default.
• W2039980771 cites W1996962820 @default.
• W2039980771 cites W2004411023 @default.
• W2039980771 cites W2005545469 @default.
• W2039980771 cites W2006807640 @default.
• W2039980771 cites W2009787851 @default.
• W2039980771 cites W2010744192 @default.
• W2039980771 cites W2015875316 @default.
• W2039980771 cites W2020022685 @default.
• W2039980771 cites W2045289571 @default.
• W2039980771 cites W2046319893 @default.
• W2039980771 cites W2056348510 @default.
• W2039980771 cites W2056894402 @default.
• W2039980771 cites W2066158818 @default.
• W2039980771 cites W2067173540 @default.
• W2039980771 cites W2073724246 @default.
• W2039980771 cites W2076262009 @default.
• W2039980771 cites W2091279729 @default.
• W2039980771 cites W2116253673 @default.
• W2039980771 doi "https://doi.org/10.1080/00498250210124156" @default.
• W2039980771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12160481" @default.
• W2039980771 hasPublicationYear "2002" @default.
• W2039980771 type Work @default.
• W2039980771 sameAs 2039980771 @default.
• W2039980771 citedByCount "34" @default.
• W2039980771 countsByYear W20399807712012 @default.
• W2039980771 countsByYear W20399807712013 @default.
• W2039980771 countsByYear W20399807712014 @default.
• W2039980771 countsByYear W20399807712015 @default.
• W2039980771 countsByYear W20399807712017 @default.
• W2039980771 countsByYear W20399807712018 @default.
• W2039980771 countsByYear W20399807712020 @default.
• W2039980771 countsByYear W20399807712021 @default.
• W2039980771 crossrefType "journal-article" @default.
• W2039980771 hasAuthorship W2039980771A5017217956 @default.
• W2039980771 hasAuthorship W2039980771A5018207002 @default.
• W2039980771 hasAuthorship W2039980771A5028056295 @default.
• W2039980771 hasAuthorship W2039980771A5031520863 @default.
• W2039980771 hasAuthorship W2039980771A5060535056 @default.
• W2039980771 hasAuthorship W2039980771A5064846441 @default.
• W2039980771 hasConcept C107872376 @default.
• W2039980771 hasConcept C115448650 @default.
• W2039980771 hasConcept C134306372 @default.
• W2039980771 hasConcept C179998833 @default.
• W2039980771 hasConcept C181199279 @default.
• W2039980771 hasConcept C185592680 @default.
• W2039980771 hasConcept C18903297 @default.
• W2039980771 hasConcept C197336794 @default.
• W2039980771 hasConcept C2776332788 @default.
• W2039980771 hasConcept C2777477808 @default.
• W2039980771 hasConcept C33923547 @default.
• W2039980771 hasConcept C43617362 @default.
• W2039980771 hasConcept C55493867 @default.
• W2039980771 hasConcept C62231903 @default.
• W2039980771 hasConcept C66974803 @default.
• W2039980771 hasConcept C71240020 @default.
• W2039980771 hasConcept C86803240 @default.
• W2039980771 hasConcept C89311334 @default.
• W2039980771 hasConceptScore W2039980771C107872376 @default.
• W2039980771 hasConceptScore W2039980771C115448650 @default.
• W2039980771 hasConceptScore W2039980771C134306372 @default.
• W2039980771 hasConceptScore W2039980771C179998833 @default.
• W2039980771 hasConceptScore W2039980771C181199279 @default.
• W2039980771 hasConceptScore W2039980771C185592680 @default.
• W2039980771 hasConceptScore W2039980771C18903297 @default.
• W2039980771 hasConceptScore W2039980771C197336794 @default.
• W2039980771 hasConceptScore W2039980771C2776332788 @default.
• W2039980771 hasConceptScore W2039980771C2777477808 @default.
• W2039980771 hasConceptScore W2039980771C33923547 @default.
• W2039980771 hasConceptScore W2039980771C43617362 @default.
• W2039980771 hasConceptScore W2039980771C55493867 @default.
• W2039980771 hasConceptScore W2039980771C62231903 @default.
• W2039980771 hasConceptScore W2039980771C66974803 @default.
• W2039980771 hasConceptScore W2039980771C71240020 @default.
• W2039980771 hasConceptScore W2039980771C86803240 @default.
• W2039980771 hasConceptScore W2039980771C89311334 @default.
• W2039980771 hasIssue "6" @default.
• W2039980771 hasLocation W20399807711 @default.
• W2039980771 hasLocation W20399807712 @default.
• W2039980771 hasOpenAccess W2039980771 @default.
• W2039980771 hasPrimaryLocation W20399807711 @default.
• W2039980771 hasRelatedWork W1965829556 @default.
• W2039980771 hasRelatedWork W2021814780 @default.
• W2039980771 hasRelatedWork W2039980771 @default.
• W2039980771 hasRelatedWork W2164283682 @default.
• W2039980771 hasRelatedWork W2266055413 @default.

• next