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• W2039984281 abstract "The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more sensitive methods which are usually applied in aligning inter-species sequences.Here we present a new algorithm called CAT (for Cross-species Alignment Tool). It is designed to align mRNA sequences to mammalian-sized genomes. CAT is implemented using C scripts and is freely available on the web at http://xat.sourceforge.net/.Examined from different angles, CAT outperforms other extant alignment tools. Tested against all available mouse-human and zebrafish-human orthologs, we demonstrate that CAT combines the specificity and speed of the best intra-species algorithms, like BLAT and sim4, with the sensitivity of the best inter-species tools, like GeneWise." @default.
• W2039984281 created "2016-06-24" @default.
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• W2039984281 date "2007-09-19" @default.
• W2039984281 modified "2023-10-17" @default.
• W2039984281 title "A cross-species alignment tool (CAT)" @default.
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• W2039984281 doi "https://doi.org/10.1186/1471-2105-8-349" @default.
• W2039984281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2082505" @default.
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