FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039997061> ?p ?o ?g. }

• W2039997061 endingPage "14714" @default.
• W2039997061 startingPage "14709" @default.
• W2039997061 abstract "Autoimmune polyendocrinopathy syndrome type 1 (APS1) results from homozygous Aire mutations that cripple thymic deletion of organ-specific T cells. The clinical course in man and mouse is characterized by high variability both in the latent period before onset of autoimmune disease and in the specific organs affected, but the reasons for this are unknown. Here we test the hypothesis that the latent period reflects the failsafe action of discrete postthymic mechanisms for imposing self-tolerance in peripheral T cells. Aire -deficient mice were crossed with mice of a uniform major histocompatibility complex (MHC) haplotype and genetic background carrying specific genetic defects in one of four distinct peripheral tolerance mechanisms: activation-induced cell death ( Fasl gld/gld ), anergy and requirement for CD28 costimulation ( Cblb −/− ), inhibition of ICOS and T FH cells ( Rc3h1 san/san ), or decreased numbers of Foxp3 + T regulatory cells ( Card11 unm/unm ). Cblb -deficiency was unique among these four in precipitating rapid clinical autoimmune disease when combined with Aire -deficiency, resulting in autoimmune exocrine pancreatitis with median age of survival of only 25 d. Massive lymphocytic infiltration selectively destroyed most of the exocrine acinar cells of the pancreas and submandibular salivary gland, and CD4 + and CD8 + subsets were necessary and sufficient to transfer the disease. Intrinsic regulation of peripheral T cells by CBL-B thus serves a uniquely critical role as a failsafe against clinical onset of autoimmune disease in AIRE deficiency, and multiple peripheral tolerance mechanisms may need to fail before onset of clinical autoimmunity to many organs." @default.
• W2039997061 created "2016-06-24" @default.
• W2039997061 creator A5023475848 @default.
• W2039997061 creator A5070851567 @default.
• W2039997061 creator A5071379424 @default.
• W2039997061 creator A5076145181 @default.
• W2039997061 date "2010-07-28" @default.
• W2039997061 modified "2023-09-23" @default.
• W2039997061 title "T-cell regulation by <i>casitas B-lineage lymphoma</i> ( <i>Cblb</i> ) is a critical failsafe against autoimmune disease due to <i>autoimmune regulator</i> ( <i>Aire</i> ) deficiency" @default.
• W2039997061 cites W1513014113 @default.
• W2039997061 cites W1539328666 @default.
• W2039997061 cites W1583317594 @default.
• W2039997061 cites W1583426224 @default.
• W2039997061 cites W1596079370 @default.
• W2039997061 cites W1973853837 @default.
• W2039997061 cites W1985533946 @default.
• W2039997061 cites W1995110654 @default.
• W2039997061 cites W1999041896 @default.
• W2039997061 cites W2004282938 @default.
• W2039997061 cites W2007362831 @default.
• W2039997061 cites W2007829567 @default.
• W2039997061 cites W2011108094 @default.
• W2039997061 cites W2015166017 @default.
• W2039997061 cites W2016265097 @default.
• W2039997061 cites W2016976370 @default.
• W2039997061 cites W2018703348 @default.
• W2039997061 cites W2024060364 @default.
• W2039997061 cites W2024108088 @default.
• W2039997061 cites W2028222510 @default.
• W2039997061 cites W2031622194 @default.
• W2039997061 cites W2039096179 @default.
• W2039997061 cites W2039253450 @default.
• W2039997061 cites W2058924454 @default.
• W2039997061 cites W2061071534 @default.
• W2039997061 cites W2062506591 @default.
• W2039997061 cites W2073279878 @default.
• W2039997061 cites W2075330371 @default.
• W2039997061 cites W2076067786 @default.
• W2039997061 cites W2083737302 @default.
• W2039997061 cites W2097289995 @default.
• W2039997061 cites W2105841943 @default.
• W2039997061 cites W2108758471 @default.
• W2039997061 cites W2115316309 @default.
• W2039997061 cites W2117243834 @default.
• W2039997061 cites W2131484200 @default.
• W2039997061 cites W2138278594 @default.
• W2039997061 cites W2143848915 @default.
• W2039997061 cites W2143902379 @default.
• W2039997061 cites W2150004911 @default.
• W2039997061 cites W2156554590 @default.
• W2039997061 cites W2165214298 @default.
• W2039997061 cites W2179862924 @default.
• W2039997061 cites W4211183651 @default.
• W2039997061 doi "https://doi.org/10.1073/pnas.1009209107" @default.
• W2039997061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2930471" @default.
• W2039997061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20668237" @default.
• W2039997061 hasPublicationYear "2010" @default.
• W2039997061 type Work @default.
• W2039997061 sameAs 2039997061 @default.
• W2039997061 citedByCount "36" @default.
• W2039997061 countsByYear W20399970612012 @default.
• W2039997061 countsByYear W20399970612013 @default.
• W2039997061 countsByYear W20399970612014 @default.
• W2039997061 countsByYear W20399970612015 @default.
• W2039997061 countsByYear W20399970612016 @default.
• W2039997061 countsByYear W20399970612017 @default.
• W2039997061 countsByYear W20399970612018 @default.
• W2039997061 countsByYear W20399970612019 @default.
• W2039997061 countsByYear W20399970612020 @default.
• W2039997061 countsByYear W20399970612021 @default.
• W2039997061 countsByYear W20399970612022 @default.
• W2039997061 countsByYear W20399970612023 @default.
• W2039997061 crossrefType "journal-article" @default.
• W2039997061 hasAuthorship W2039997061A5023475848 @default.
• W2039997061 hasAuthorship W2039997061A5070851567 @default.
• W2039997061 hasAuthorship W2039997061A5071379424 @default.
• W2039997061 hasAuthorship W2039997061A5076145181 @default.
• W2039997061 hasBestOaLocation W20399970611 @default.
• W2039997061 hasConcept C104317684 @default.
• W2039997061 hasConcept C12387725 @default.
• W2039997061 hasConcept C127716648 @default.
• W2039997061 hasConcept C159654299 @default.
• W2039997061 hasConcept C190283241 @default.
• W2039997061 hasConcept C203014093 @default.
• W2039997061 hasConcept C207936829 @default.
• W2039997061 hasConcept C2776090121 @default.
• W2039997061 hasConcept C2776566471 @default.
• W2039997061 hasConcept C2777016536 @default.
• W2039997061 hasConcept C2778296632 @default.
• W2039997061 hasConcept C2778959938 @default.
• W2039997061 hasConcept C2779075594 @default.
• W2039997061 hasConcept C2779727006 @default.
• W2039997061 hasConcept C2780130043 @default.
• W2039997061 hasConcept C3031857 @default.
• W2039997061 hasConcept C31573885 @default.
• W2039997061 hasConcept C54355233 @default.
• W2039997061 hasConcept C79484868 @default.
• W2039997061 hasConcept C86803240 @default.

• next