Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040000788> ?p ?o ?g. }
- W2040000788 endingPage "196" @default.
- W2040000788 startingPage "187" @default.
- W2040000788 abstract "The aim of this study was to prepare stable formulations of poorly water-soluble drugs in amorphous forms to enhance their dissolution rates, promote the bioavailability, minimize the dosage, thereby theoretically decreasing their side effects. A dense gas solvent exchange process was developed for the impregnation of poorly water-soluble drugs such as camptothecin and griseofulvin into a chitosan matrix. The amount of drug impregnated was measured by UV-spectrophotometery and gravimetric techniques. Pore characteristics and the crystallinity of the drugs in the impregnated chitosan were measured. Homogenous nano-sized pores with thin walls were formed in chitosan using the dense gas solvent exchange process. The method was efficient for the impregnation of a drug into chitosan. Results of XRD, Fourier transform infrared spectroscopy and differential scanning calorimetry demonstrated that as a result of interaction between chitosan and the drug, both camptothecin and griseofulvin were in amorphous forms after processing. The dissolution rate of processed griseofulvin was increased threefold due to the hydrophilic properties of chitosan and its interaction with the drug. A new approach was developed for promoting drug bioavailability that has the potential to decrease the required dose and side effects, particularly for chemotherapeutic drugs with narrow therapeutic index." @default.
- W2040000788 created "2016-06-24" @default.
- W2040000788 creator A5015794408 @default.
- W2040000788 creator A5050481405 @default.
- W2040000788 creator A5067838410 @default.
- W2040000788 creator A5069374909 @default.
- W2040000788 creator A5075520869 @default.
- W2040000788 date "2010-05-01" @default.
- W2040000788 modified "2023-09-28" @default.
- W2040000788 title "The development of a dense gas solvent exchange process for the impregnation of pharmaceuticals into porous chitosan" @default.
- W2040000788 cites W1953268689 @default.
- W2040000788 cites W1964189315 @default.
- W2040000788 cites W1970750881 @default.
- W2040000788 cites W1973229108 @default.
- W2040000788 cites W1978424120 @default.
- W2040000788 cites W1984734563 @default.
- W2040000788 cites W2001240823 @default.
- W2040000788 cites W2004620214 @default.
- W2040000788 cites W2010247478 @default.
- W2040000788 cites W2011694905 @default.
- W2040000788 cites W2015294728 @default.
- W2040000788 cites W2019661598 @default.
- W2040000788 cites W2029318995 @default.
- W2040000788 cites W2031172597 @default.
- W2040000788 cites W2032242147 @default.
- W2040000788 cites W2037468206 @default.
- W2040000788 cites W2038636428 @default.
- W2040000788 cites W2040340022 @default.
- W2040000788 cites W2045819283 @default.
- W2040000788 cites W2049221872 @default.
- W2040000788 cites W2057436175 @default.
- W2040000788 cites W2063849251 @default.
- W2040000788 cites W2064879026 @default.
- W2040000788 cites W2065448687 @default.
- W2040000788 cites W2067741455 @default.
- W2040000788 cites W2067982086 @default.
- W2040000788 cites W2071159517 @default.
- W2040000788 cites W2077565640 @default.
- W2040000788 cites W2078751203 @default.
- W2040000788 cites W2080022611 @default.
- W2040000788 cites W2081441405 @default.
- W2040000788 cites W2081833333 @default.
- W2040000788 cites W2090296204 @default.
- W2040000788 cites W2091619770 @default.
- W2040000788 cites W2102612249 @default.
- W2040000788 cites W2102803971 @default.
- W2040000788 cites W2104948210 @default.
- W2040000788 cites W2124905988 @default.
- W2040000788 cites W2170292180 @default.
- W2040000788 cites W2314262462 @default.
- W2040000788 cites W2481543387 @default.
- W2040000788 cites W4239097914 @default.
- W2040000788 doi "https://doi.org/10.1016/j.ijpharm.2010.03.006" @default.
- W2040000788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20214968" @default.
- W2040000788 hasPublicationYear "2010" @default.
- W2040000788 type Work @default.
- W2040000788 sameAs 2040000788 @default.
- W2040000788 citedByCount "18" @default.
- W2040000788 countsByYear W20400007882012 @default.
- W2040000788 countsByYear W20400007882013 @default.
- W2040000788 countsByYear W20400007882014 @default.
- W2040000788 countsByYear W20400007882015 @default.
- W2040000788 countsByYear W20400007882016 @default.
- W2040000788 countsByYear W20400007882017 @default.
- W2040000788 countsByYear W20400007882019 @default.
- W2040000788 countsByYear W20400007882020 @default.
- W2040000788 crossrefType "journal-article" @default.
- W2040000788 hasAuthorship W2040000788A5015794408 @default.
- W2040000788 hasAuthorship W2040000788A5050481405 @default.
- W2040000788 hasAuthorship W2040000788A5067838410 @default.
- W2040000788 hasAuthorship W2040000788A5069374909 @default.
- W2040000788 hasAuthorship W2040000788A5075520869 @default.
- W2040000788 hasConcept C121332964 @default.
- W2040000788 hasConcept C127413603 @default.
- W2040000788 hasConcept C13965031 @default.
- W2040000788 hasConcept C142724271 @default.
- W2040000788 hasConcept C160892712 @default.
- W2040000788 hasConcept C178790620 @default.
- W2040000788 hasConcept C181389837 @default.
- W2040000788 hasConcept C185592680 @default.
- W2040000788 hasConcept C192562407 @default.
- W2040000788 hasConcept C2779732960 @default.
- W2040000788 hasConcept C2779819575 @default.
- W2040000788 hasConcept C2780471494 @default.
- W2040000788 hasConcept C39519442 @default.
- W2040000788 hasConcept C42360764 @default.
- W2040000788 hasConcept C43617362 @default.
- W2040000788 hasConcept C46275449 @default.
- W2040000788 hasConcept C71924100 @default.
- W2040000788 hasConcept C77281830 @default.
- W2040000788 hasConcept C8010536 @default.
- W2040000788 hasConcept C88380143 @default.
- W2040000788 hasConcept C97355855 @default.
- W2040000788 hasConcept C98274493 @default.
- W2040000788 hasConceptScore W2040000788C121332964 @default.
- W2040000788 hasConceptScore W2040000788C127413603 @default.
- W2040000788 hasConceptScore W2040000788C13965031 @default.
- W2040000788 hasConceptScore W2040000788C142724271 @default.