FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040005994> ?p ?o ?g. }

• W2040005994 endingPage "463" @default.
• W2040005994 startingPage "452" @default.
• W2040005994 abstract "High-energy protons found in the space environment can induce mutations and cancer, which are inextricably linked. We hypothesized that some mutants isolated from proton-exposed kidneys arose through a genome-wide incident that causes loss of heterozygosity (LOH)-generating mutations on multiple chromosomes (termed here genomic LOH). To test this hypothesis, we examined 11 pairs of nonselected chromosomes for LOH events in mutant cells isolated from the kidneys of mice exposed to 4 or 5 Gy of 1 GeV protons. The mutant kidney cells were selected for loss of expression of the chromosome 8-encoded Aprt gene. Genomic LOH events were also assessed in Aprt mutants isolated from isogenic cultured kidney epithelial cells exposed to 5 Gy of protons in vitro. Control groups were spontaneous Aprt mutants and clones isolated without selection from the proton-exposed kidneys or cultures. The in vivo results showed significant increases in genomic LOH events in the Aprt mutants from proton-exposed kidneys when compared with spontaneous Aprt mutants and when compared with nonmutant (i.e., nonselected) clones from the proton-exposed kidneys. A bias for LOH events affecting chromosome 14 was observed in the proton-induced Aprt mutants, though LOH for this chromosome did not confer increased radiation resistance. Genomic LOH events were observed in Aprt mutants isolated from proton-exposed cultured kidney cells; however the incidence was fivefold lower than in Aprt mutants isolated from exposed intact kidneys, suggesting a more permissive environment in the intact organ and/or the evolution of kidney clones prior to their isolation from the tissue. We conclude that proton exposure creates a subset of viable cells with LOH events on multiple chromosomes, that these cells form and persist in vivo, and that they can be isolated from an intact tissue by selection for a mutation on a single chromosome." @default.
• W2040005994 created "2016-06-24" @default.
• W2040005994 creator A5000506055 @default.
• W2040005994 creator A5008751957 @default.
• W2040005994 creator A5016128720 @default.
• W2040005994 creator A5023902327 @default.
• W2040005994 creator A5047631946 @default.
• W2040005994 creator A5054180902 @default.
• W2040005994 creator A5059867730 @default.
• W2040005994 creator A5062347432 @default.
• W2040005994 creator A5068111644 @default.
• W2040005994 creator A5071648060 @default.
• W2040005994 date "2014-05-01" @default.
• W2040005994 modified "2023-09-24" @default.
• W2040005994 title "Autosomal Mutants of Proton-Exposed Kidney Cells Display Frequent Loss of Heterozygosity on Nonselected Chromosomes" @default.
• W2040005994 cites W163659664 @default.
• W2040005994 cites W1717569302 @default.
• W2040005994 cites W1951958894 @default.
• W2040005994 cites W1969173539 @default.
• W2040005994 cites W1971041386 @default.
• W2040005994 cites W1971700019 @default.
• W2040005994 cites W1974925253 @default.
• W2040005994 cites W1977373878 @default.
• W2040005994 cites W1979000953 @default.
• W2040005994 cites W1984688561 @default.
• W2040005994 cites W1985631251 @default.
• W2040005994 cites W1986870670 @default.
• W2040005994 cites W1994863270 @default.
• W2040005994 cites W2004282309 @default.
• W2040005994 cites W2007693751 @default.
• W2040005994 cites W2008512916 @default.
• W2040005994 cites W2017121946 @default.
• W2040005994 cites W2017295550 @default.
• W2040005994 cites W2025338451 @default.
• W2040005994 cites W2038274123 @default.
• W2040005994 cites W2038745409 @default.
• W2040005994 cites W2044014838 @default.
• W2040005994 cites W2046928699 @default.
• W2040005994 cites W2048947459 @default.
• W2040005994 cites W2051224479 @default.
• W2040005994 cites W2053388587 @default.
• W2040005994 cites W2061995059 @default.
• W2040005994 cites W2067055574 @default.
• W2040005994 cites W2068755461 @default.
• W2040005994 cites W2069015999 @default.
• W2040005994 cites W2071411183 @default.
• W2040005994 cites W2071929035 @default.
• W2040005994 cites W2074634521 @default.
• W2040005994 cites W2077956757 @default.
• W2040005994 cites W2080666790 @default.
• W2040005994 cites W2088313285 @default.
• W2040005994 cites W2088948537 @default.
• W2040005994 cites W2098806119 @default.
• W2040005994 cites W2103941628 @default.
• W2040005994 cites W2116365996 @default.
• W2040005994 cites W2117315026 @default.
• W2040005994 cites W2118094114 @default.
• W2040005994 cites W2118360398 @default.
• W2040005994 cites W2121378993 @default.
• W2040005994 cites W2122382992 @default.
• W2040005994 cites W2124203681 @default.
• W2040005994 cites W2125426824 @default.
• W2040005994 cites W2134590240 @default.
• W2040005994 cites W2136943372 @default.
• W2040005994 cites W2140588561 @default.
• W2040005994 cites W2143326482 @default.
• W2040005994 cites W2145954753 @default.
• W2040005994 cites W2149527854 @default.
• W2040005994 cites W2151771618 @default.
• W2040005994 cites W2153517333 @default.
• W2040005994 cites W2155269488 @default.
• W2040005994 cites W2159886061 @default.
• W2040005994 cites W2164811914 @default.
• W2040005994 cites W2165699169 @default.
• W2040005994 cites W2165734801 @default.
• W2040005994 cites W2178925418 @default.
• W2040005994 cites W2180350198 @default.
• W2040005994 cites W2220580282 @default.
• W2040005994 cites W2283696255 @default.
• W2040005994 cites W255240917 @default.
• W2040005994 cites W306261631 @default.
• W2040005994 cites W1663180550 @default.
• W2040005994 cites W1995451939 @default.
• W2040005994 doi "https://doi.org/10.1667/rr13654.1" @default.
• W2040005994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24758577" @default.
• W2040005994 hasPublicationYear "2014" @default.
• W2040005994 type Work @default.
• W2040005994 sameAs 2040005994 @default.
• W2040005994 citedByCount "4" @default.
• W2040005994 countsByYear W20400059942017 @default.
• W2040005994 countsByYear W20400059942020 @default.
• W2040005994 crossrefType "journal-article" @default.
• W2040005994 hasAuthorship W2040005994A5000506055 @default.
• W2040005994 hasAuthorship W2040005994A5008751957 @default.
• W2040005994 hasAuthorship W2040005994A5016128720 @default.
• W2040005994 hasAuthorship W2040005994A5023902327 @default.
• W2040005994 hasAuthorship W2040005994A5047631946 @default.
• W2040005994 hasAuthorship W2040005994A5054180902 @default.

• next