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- W2040020417 abstract "Evoked potentials were recorded in Larsell's lobules VI, VIIB and the left paramedian lobule of the cerebellum in adult cats anaesthetized with ketamine hydrochloride (Vetelar ® ) and α-chloralose. Diphenylhydantoin (Dilantin ® ) reduced auditory responses produced by a 2800 Hz 60 dB tone in all three cerebellar areas, 5 mg/kg being below threshold and doses of 20 mg/kg or more completely abolishing the response. In addition, cerebellar responses produced by dropping a 10-g weight on the forepaw or stimulation of the ipsilateral superficial radial nerve were resistant to diphenylhydantoin doses as great as 40 mg/kg. The onset time was 15–30 min and the duration of the depression was in excess of 6 hr in most experiments. Diphenylhydantoin seemed to have no effect on spontaneous cerebellar activity. Ketamine produced a short-lived depression of cerebellar evoked potentials, lasting less than 1 hr. α-Chloralosc produced substantial depression of evoked potentials only at exceedingly large doses, with little effect observed with the doses required for anaesthesia. Therefore, the selective depression of auditory-evoked cerebellar activity is due to diphenylhydantoin." @default.
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- W2040020417 title "Selective diphenylhydantoin suppression of auditory evoked potentials in the cat cerebellar cortex" @default.
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- W2040020417 doi "https://doi.org/10.1016/0028-3908(74)90021-5" @default.
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