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- W2040021804 abstract "It is known that for a fixed amount of injected tracer, the amount available for a tissue of interest will be less if other tissues show intense uptake. The aim of this study was to estimate the magnitude of 2-deoxy-2-[18F]fluoro-d-glucose (18FDG) uptake amount in physiological tissues that may show an intense uptake in current clinical practice. A formula was established providing an estimate of the percentage of injected 18FDG molecules (P; in %) that are irreversibly trapped in an 18FDG-positive tissue during a PET examination. P ≅ 0.17*exp(−λtacq)*TLG/W, where λ is the 18F physical decay constant, tacq is the injection-acquisition time delay, TLG is total lesion glycolysis (g) and W is the patient weight (kg). The magnitude of P was calculated in two patients showing an intense uptake in brown fat, myocardium and bowels: 0.5, 3.5, and 4.2% respectively. A formula is available to quickly estimate the amount of 18FDG uptake in tissues. We suggest that the accumulation of different physiological uptakes may actually affect SUV quantification in a tissue of interest." @default.
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- W2040021804 date "2014-10-01" @default.
- W2040021804 modified "2023-09-26" @default.
- W2040021804 title "Estimating the amount of FDG uptake in physiological tissues" @default.
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- W2040021804 doi "https://doi.org/10.1016/j.nucmedbio.2014.06.003" @default.
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