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• W2040022956 abstract "We present a protocol for the very rapid and sensitive detection of a specific mutation of the COL4A5 gene (exon 29, A−C mismatch) which was found in people affected by Alport syndrome (AS) and their families. Disposable electrochemically printed electrodes were used to immobilize a single-stranded oligonucleotide probe that was complementary to the AS-correlated gene. The detection principle is based on changes in the impedance spectra of the redox probe ferro/ferricyanide after hybridization with synthetic target DNA. Detection was performed either for mutated or for healthy (wild-type) gene copies. The high sensitivity obtained with this protocol (LOD in the picomolar range) was additionally enhanced to the femtomolar range by performing the detection in the presence of Ca2+. In fact, the specific binding of the metal ions in the presence of an A−C nucleotide mismatch induced a further impedance change, thus improving the discrimination between the mutated and healthy gene, as the signal amplification is achieved only for the former." @default.
• W2040022956 created "2016-06-24" @default.
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• W2040022956 date "2010-04-05" @default.
• W2040022956 modified "2023-10-16" @default.
• W2040022956 title "Rapid, Sensitive, and Label-Free Impedimetric Detection of a Single-Nucleotide Polymorphism Correlated to Kidney Disease" @default.
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• W2040022956 doi "https://doi.org/10.1021/ac100165q" @default.
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